Techno-economic analysis of separation processes for continuous pharmaceutical manufacturing: Assessing process performance, material efficiency and economic viability

Samir Diab, Dimitrios I. Gerogiorgis*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The pharmaceutical industry is currently dominated by the traditionally implemented, yet wasteful and inefficient, batch production paradigm. Continuous Pharmaceutical Manufacturing (CPM) shows potential to bring technological innovation, cost savings and environmental benefits to pharmaceutical production. This paper describes the process modelling and simulation of CPM of two active pharmaceutical ingredients (APIs): diphenhydramine (a globally-marketed antishistamine) and artemisinin (an important antimalarial drug), with focus on implementing a continuous separation process for each. The continuous liquid-liquid extraction of diphenhydramine and continuous crystallisation of artemisinin are compared to the batch methods, in order to demonstrate the benefits of material efficiency and economic viability of continuous separations in pharmaceutical manufacturing.

Original languageEnglish
Pages (from-to)14-17
Number of pages4
JournalChemistry Today
Volume35
Issue number2
Publication statusPublished - 1 May 2017

Keywords

  • Continuous Pharmaceutical Manufacturing (CPM)
  • design
  • separations
  • diphenhydramine
  • artemisinin
  • economics
  • FLOW CHEMISTRY
  • PURIFICATION
  • ARTEMISININ
  • INGREDIENTS
  • PERSPECTIVE
  • INDUSTRY
  • DESIGN

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