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Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice
Anahita Mojiri
, Brandon K Walther
, Chongming Jiang
,
Gianfranco Matrone
, Rhonda Holgate
, Qiu Xu
, Elisa Morales
, Guangyu Wang
, Jianhua Gu
, Rongfu Wang
, John P Cooke
*
*
Corresponding author for this work
School of Regeneration and Repair
Centre for Cardiovascular Science
Research output
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Article
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peer-review
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Medicine and Dentistry
Lifespan
100%
Progeria
100%
Telomerase
100%
Endothelial Cell
54%
DNA Damage
27%
Induced Pluripotent Stem Cell
18%
Sirtuin1
18%
Telomere
18%
Messenger RNA
18%
Progerin
18%
Apoplexy
9%
Gene Expression
9%
Prematurity
9%
Angiogenesis
9%
Genetic Transfection
9%
Vascularity
9%
Lamin A
9%
Nitric Oxide
9%
Lentivirus
9%
Myocardial Infarction
9%
Endothelial Function
9%
Accelerated Aging
9%
Rejuvenation
9%
Inflammatory Cytokine
9%
Vascular Disease
9%
Diseases
9%
Proteomics
9%
Biochemistry, Genetics and Molecular Biology
Telomerase
100%
Lifespan
100%
Progeria
100%
DNA Damage
27%
Sirtuin1
18%
Induced Pluripotent Stem Cell
18%
Messenger RNA
18%
Telomere
18%
Progerin
18%
Mouse Model
9%
Vascularization
9%
Inflammatory Cytokine
9%
Gene Expression
9%
Transfection
9%
Nitric Oxide
9%
Angiogenesis
9%
Lentivirus
9%
Lamin
9%
Proteomics
9%