Telomere length and physical performance at older ages: an individual participant meta-analysis

Michael P Gardner; Carmen Martin-Ruiz; Rachel Cooper; Rebecca Hardy; Avan Aihie Sayer; Cyrus Cooper; Ian J Deary; John Gallacher; Sarah E Harris; Paul G Shiels; John M Starr; Diana Kuh; Thomas von Zglinicki; Yoav Ben-Shlomo; Halcyon study team

doi:10.1371/journal.pone.0069526

Telomere length and physical performance at older ages: an individual participant meta-analysis

Michael P Gardner, Carmen Martin-Ruiz, Rachel Cooper, Rebecca Hardy, Avan Aihie Sayer, Cyrus Cooper, Ian J Deary, John Gallacher, Sarah E Harris, Paul G Shiels, John M Starr, Diana Kuh, Thomas von Zglinicki, Yoav Ben-Shlomo, Halcyon study team

Research output: Contribution to journal › Article › peer-review

Abstract

Telomeres are involved in cellular ageing and shorten with increasing age. If telomere length is a valuable biomarker of ageing, then telomere shortening should be associated with worse physical performance, an ageing trait, but evidence for such an association is lacking. The purpose of this study was to examine whether change in telomere length is associated with physical performance.

Original language	English
Pages (from-to)	e69526
Journal	PLoS ONE
Volume	8
Issue number	7
DOIs	https://doi.org/10.1371/journal.pone.0069526
Publication status	Published - 2013

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Telomere length and physical performance at older agesFinal published version, 428 KB

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0069526

RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.
Deary, I. (Principal Investigator), Gale, C. (Co-investigator), Holmes, M. (Co-investigator), Logie, P. (Co-investigator), Maclullich, A. (Co-investigator), Porteous, D. (Co-investigator), Seckl, J. (Co-investigator), Starr, J. (Co-investigator), Wardlaw, J. (Co-investigator) & Okely, J. (Researcher)
1/09/13 → 31/08/19
Project: Research
MRC Centre for Cognitive Ageing and Cognitive Epidemiology
Deary, I. (Principal Investigator), Holmes, M. (Co-investigator), Logie, P. (Co-investigator), McCulloch, J. (Co-investigator), Porteous, D. (Co-investigator), Roberts, N. (Co-investigator), Seckl, J. (Co-investigator), Starr, J. (Co-investigator) & Wardlaw, J. (Co-investigator)
MRC
1/09/08 → 31/08/13
Project: Research
A Life course approach to healthy ageing: Capitalising on the value of UK course cohorts
Deary, I. (Principal Investigator)
MRC
1/09/08 → 31/03/13
Project: Research

Cite this

Gardner, M. P., Martin-Ruiz, C., Cooper, R., Hardy, R., Sayer, A. A., Cooper, C., Deary, I. J., Gallacher, J., Harris, S. E., Shiels, P. G., Starr, J. M., Kuh, D., von Zglinicki, T., Ben-Shlomo, Y., & Halcyon study team (2013). Telomere length and physical performance at older ages: an individual participant meta-analysis. PLoS ONE, 8(7), e69526. https://doi.org/10.1371/journal.pone.0069526

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abstract = "Telomeres are involved in cellular ageing and shorten with increasing age. If telomere length is a valuable biomarker of ageing, then telomere shortening should be associated with worse physical performance, an ageing trait, but evidence for such an association is lacking. The purpose of this study was to examine whether change in telomere length is associated with physical performance.",

author = "Gardner, {Michael P} and Carmen Martin-Ruiz and Rachel Cooper and Rebecca Hardy and Sayer, {Avan Aihie} and Cyrus Cooper and Deary, {Ian J} and John Gallacher and Harris, {Sarah E} and Shiels, {Paul G} and Starr, {John M} and Diana Kuh and {von Zglinicki}, Thomas and Yoav Ben-Shlomo and {Halcyon study team} and Geraldine Mcneill",

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Gardner, MP, Martin-Ruiz, C, Cooper, R, Hardy, R, Sayer, AA, Cooper, C, Deary, IJ, Gallacher, J, Harris, SE, Shiels, PG, Starr, JM, Kuh, D, von Zglinicki, T, Ben-Shlomo, Y & Halcyon study team 2013, 'Telomere length and physical performance at older ages: an individual participant meta-analysis', PLoS ONE, vol. 8, no. 7, pp. e69526. https://doi.org/10.1371/journal.pone.0069526

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AU - Gardner, Michael P

AU - Martin-Ruiz, Carmen

AU - Cooper, Rachel

AU - Hardy, Rebecca

AU - Sayer, Avan Aihie

AU - Cooper, Cyrus

AU - Deary, Ian J

AU - Gallacher, John

AU - Harris, Sarah E

AU - Shiels, Paul G

AU - Starr, John M

AU - Kuh, Diana

AU - von Zglinicki, Thomas

AU - Ben-Shlomo, Yoav

AU - Halcyon study team

AU - Mcneill, Geraldine

PY - 2013

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AB - Telomeres are involved in cellular ageing and shorten with increasing age. If telomere length is a valuable biomarker of ageing, then telomere shortening should be associated with worse physical performance, an ageing trait, but evidence for such an association is lacking. The purpose of this study was to examine whether change in telomere length is associated with physical performance.

U2 - 10.1371/journal.pone.0069526

DO - 10.1371/journal.pone.0069526

M3 - Article

C2 - 23922731

SN - 1932-6203

VL - 8

SP - e69526

JO - PLoS ONE

JF - PLoS ONE

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ER -

Telomere length and physical performance at older ages: an individual participant meta-analysis

Abstract

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Projects

RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.

MRC Centre for Cognitive Ageing and Cognitive Epidemiology

A Life course approach to healthy ageing: Capitalising on the value of UK course cohorts

Cite this