Abstract / Description of output
Objective Galectin-3 is a pro-inflammatory, pro-fibrotic molecule implicated in the pathogenesis of heart failure, and associated with poor prognostic outcome. When measured following ST-elevation myocardial infarction (STEMI), a high plasma galectin-3 predicts greater 30-day morbidity and mortality, and increased heart failure incidence at a median of 2 years. This study aims to elucidate the temporal aspects of galectin-3 expression immediately post-STE:Oland how expression relates to severity of myocardial injury.
Methods Plasma galectin-3 levels were compared in 53 STEMI patients and 23 control patients with stable angina. Consecutive plasma galectin-3 levels, measured at a mean of 30 hours (sample A) and 54 hours (Sample B) post pain, and analysis of galectin-3 vs time since onset of pain/time since reperfusion allowed assessment of temporal expression in STEMI patients. Myocardial injury markers included troponin and left ventricular ejection fraction (LVEF) at primary percutaneous coronary intervention (PCI).
Results Circulating galectin-3 levels were significantly higher in STEMI patients than control patients when measured at a mean of 30 hours post pain (t = 2.72, df = 66, P = 0.008). However, levels had significantly decreased when measured 24 hours later (t = 2.13, df = 47, P = 0.039), with a negative linear relationship apparent between plasma galectin-3 levels and time since reperfusion on univariate analysis (OR = 0.871, 95%CI = 0.779-0.975, P = 0.021). A significantly lower circulating galectin-3 concentration was also found for sample A in those reperfused within 3 hours post onset of pain (OR 0.045, 95%CI 0.003-0.669, P = 0.029).
Conclusions Plasma galectin-3 levels vary significantly following a STEM! over a short time period, in relation to timing of reperfusion.
Original language | English |
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Pages (from-to) | 595-602 |
Number of pages | 8 |
Journal | Acta cardiologica |
Volume | 69 |
Issue number | 6 |
DOIs | |
Publication status | Published - Dec 2014 |
Keywords / Materials (for Non-textual outputs)
- Galectin-3 ST-elevation Myocardial infarction
- PERCUTANEOUS CORONARY INTERVENTION
- CHRONIC HEART-FAILURE
- PROGNOSTIC VALUE
- FIBROSIS
- MACROPHAGES
- DYSFUNCTION
- OUTCOMES
- THERAPY
- MARKER
- TRIAL