Temporal modulation of the response of sensory fibers to paired-pulse stimulation

Emma K. Brunton, Carolina Silveira, Joshua Rosenberg, Matthew A. Schiefer, John Riddell, Kianoush Nazarpour

Research output: Contribution to journalArticlepeer-review

Abstract

Multi-channel nerve cuff electrode arrays can provide sensory feedback to prosthesis users. To develop efficacious stimulation protocols, an understanding of the impact that spatio-temporal patterned stimulation can have on the response of sensory fibers is crucial. We used experimental and modelling methods to investigate the response of nerve fibers to paired-pulse stimulation. Nerve cuff electrode arrays were implanted for stimulation of the sciatic nerves of rats and the sensory compound action potentials were recorded from the L4 dorsal root. A model of the nerve cuff electrode array and sciatic nerve was also developed. The experimental and modelling results were compared. Experiments showed that it took 8 ms for the sensory fibers to completely recover from a conditioning stimulus, regardless of the relative position of the electrodes used for stimulation. The results demonstrate that the electrodes on the cuff cannot be considered independent. Additionally, at 120% of the threshold, there is a large overlap in the fibers that were activated by the different electrodes. If a stimulus paradigm considered the electrodes as independent, stimuli from the different electrodes would need to be interleaved, and the intervals between the stimuli should be greater than 8 ms.
Original languageEnglish
Pages (from-to)1676 - 1683
Number of pages8
JournalIEEE Transactions on Neural Systems and Rehabilitation Engineering
Volume27
Issue number9
Early online date19 Aug 2019
DOIs
Publication statusPublished - 1 Sep 2019

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