Ten Common Genetic Variants Associated with Colorectal Cancer Risk Are Not Associated with Survival after Diagnosis

Albert Tenesa, Evropi Theodoratou, Farhat Din, Susan M Farrington, Roseanne Cetnarskyj, Rebecca A Barnetson, Mary E Porteous, Harry Campbell, Malcolm G Dunlop

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To date, genomewide association studies have identified 10 genetic loci associated with colorectal cancer (CRC) susceptibility. We hypothesized that these loci might also affect cancer survival.

Experimental Design: To determine whether single-nucleotide polymorphisms tagging these 10 loci influenced all-cause and CRC-specific mortality, we prospectively followed survival outcomes for 2,838 Scottish patients recruited soon after a diagnosis of CRC. Survival analysis was conducted using Cox proportional hazard models adjusted for American Joint Committee on Cancer stage, age, and sex.

Results: None of the single-nucleotide polymorphisms were found to be statistically significantly associated with all-cause or CRC-specific mortality.

Conclusions: We conclude that none of the 10 common genetic variants thus far shown to be associated with CRC risk are associated with survival from CRC.
Original languageEnglish
Pages (from-to)3754-3759
Number of pages6
JournalClinical Cancer Research
Volume16
Issue number14
DOIs
Publication statusPublished - Jul 2010

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