Terminal loop-mediated control of microRNA biogenesis

Nila Roy Choudhury; Gracjan Michlewski

doi:10.1042/BST20120053

Terminal loop-mediated control of microRNA biogenesis

Nila Roy Choudhury, Gracjan Michlewski

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Regulation of miRNA (microRNA) biogenesis shapes the profiles of miRNAs in the living cell, contributing to cell identity and function. Importantly, aberrant miRNA levels have been linked to a variety of human pathological states. In recent years, a number of proteins have been shown to regulate the miRNA biogenesis at the level of Drosha and Dicer cleavage. A large proportion of these factors regulate miRNA production through binding to the TL (terminal loop) regions of miRNA progenitors. In the present paper, we review the current knowledge about pri-miRNA (primary miRNA) and pre-miRNA (precursor miRNA) TL involvement in the regulation of miRNA biogenesis.

Original language	English
Pages (from-to)	789-793
Number of pages	5
Journal	Biochemical Society Transactions
Volume	40
Issue number	4
DOIs	https://doi.org/10.1042/BST20120053
Publication status	Published - 20 Jul 2012

Keywords / Materials (for Non-textual outputs)

heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1)
KH-type splicing regulatory protein (KSRP)
Lin28
MCP-induced protein (MCPIP1)
microRNA terminal loop
RNA-binding protein

Access to Document

10.1042/BST20120053Licence: All Rights Reserved

Cite this

@article{3f9412e93db54efe8514f6915e11170d,

title = "Terminal loop-mediated control of microRNA biogenesis",

abstract = "Regulation of miRNA (microRNA) biogenesis shapes the profiles of miRNAs in the living cell, contributing to cell identity and function. Importantly, aberrant miRNA levels have been linked to a variety of human pathological states. In recent years, a number of proteins have been shown to regulate the miRNA biogenesis at the level of Drosha and Dicer cleavage. A large proportion of these factors regulate miRNA production through binding to the TL (terminal loop) regions of miRNA progenitors. In the present paper, we review the current knowledge about pri-miRNA (primary miRNA) and pre-miRNA (precursor miRNA) TL involvement in the regulation of miRNA biogenesis.",

keywords = "heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1), KH-type splicing regulatory protein (KSRP), Lin28, MCP-induced protein (MCPIP1), microRNA terminal loop, RNA-binding protein",

author = "Choudhury, \{Nila Roy\} and Gracjan Michlewski",

year = "2012",

month = jul,

day = "20",

doi = "10.1042/BST20120053",

language = "English",

volume = "40",

pages = "789--793",

journal = "Biochemical Society Transactions",

issn = "1470-8752",

publisher = "Portland Press Ltd.",

number = "4",

}

TY - JOUR

T1 - Terminal loop-mediated control of microRNA biogenesis

AU - Choudhury, Nila Roy

AU - Michlewski, Gracjan

PY - 2012/7/20

Y1 - 2012/7/20

N2 - Regulation of miRNA (microRNA) biogenesis shapes the profiles of miRNAs in the living cell, contributing to cell identity and function. Importantly, aberrant miRNA levels have been linked to a variety of human pathological states. In recent years, a number of proteins have been shown to regulate the miRNA biogenesis at the level of Drosha and Dicer cleavage. A large proportion of these factors regulate miRNA production through binding to the TL (terminal loop) regions of miRNA progenitors. In the present paper, we review the current knowledge about pri-miRNA (primary miRNA) and pre-miRNA (precursor miRNA) TL involvement in the regulation of miRNA biogenesis.

AB - Regulation of miRNA (microRNA) biogenesis shapes the profiles of miRNAs in the living cell, contributing to cell identity and function. Importantly, aberrant miRNA levels have been linked to a variety of human pathological states. In recent years, a number of proteins have been shown to regulate the miRNA biogenesis at the level of Drosha and Dicer cleavage. A large proportion of these factors regulate miRNA production through binding to the TL (terminal loop) regions of miRNA progenitors. In the present paper, we review the current knowledge about pri-miRNA (primary miRNA) and pre-miRNA (precursor miRNA) TL involvement in the regulation of miRNA biogenesis.

KW - heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1)

KW - KH-type splicing regulatory protein (KSRP)

KW - Lin28

KW - MCP-induced protein (MCPIP1)

KW - microRNA terminal loop

KW - RNA-binding protein

U2 - 10.1042/BST20120053

DO - 10.1042/BST20120053

M3 - Article

C2 - 22817735

SN - 1470-8752

VL - 40

SP - 789

EP - 793

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 4

ER -

Terminal loop-mediated control of microRNA biogenesis

Abstract

Keywords / Materials (for Non-textual outputs)

Access to Document

Fingerprint

Cite this