Test, test, test for COVID-19 antibodies: the importance of sensitivity, specificity and predictive powers

N Kumleben, R Bhopal, T Czypionka, L Gruer, R Kock, J Stebbing, F L Stigler

Research output: Contribution to journalArticlepeer-review

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody tests of varying specificity and sensitivity are now available. For informing individuals whether they have had coronavirus disease 2019 (COVID-19), they need to be very accurate. For measuring population prevalence of past infection, the numbers of false positives and negatives need to be roughly equal. With a series of worked examples for a notional population of 100,000 people, we show that even test systems with a high specificity can yield a large number of false positive results, especially where the population prevalence is low. For example, at a true population prevalence of 5%, using a test with 99% sensitivity and specificity, 16% of positive results will be false and thus 950 people will be incorrectly informed they have had the infection. Further confirmatory testing may be needed. Giving false reassurance on which personal or societal decisions might be based could be harmful for individuals, undermine public confidence and foster further outbreaks.

Original languageEnglish
Pages (from-to)88-90
Number of pages3
JournalPublic Health
Volume185
Early online date11 Jun 2020
DOIs
Publication statusE-pub ahead of print - 11 Jun 2020

Fingerprint Dive into the research topics of 'Test, test, test for COVID-19 antibodies: the importance of sensitivity, specificity and predictive powers'. Together they form a unique fingerprint.

Cite this