Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects

R. M. Sharpe; N. E. Skakkebaek

doi:10.1016/j.fertnstert.2007.12.026

Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects

R. M. Sharpe, N. E. Skakkebaek

Deanery of Molecular, Genetic and Population Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Reproductive disorders of newborn (cryptorchidism, hypospadias) and young adult males (low sperm counts, testicular germ cell cancer) are common and/or increasing in incidence. It has been hypothesized that these disorders may comprise a testicular dysgenesis syndrome (TDS) with a common origin in fetal life. This has been supported by findings in an animal model of TDS involving fetal exposure to n(dibutyl) phthalate, as well as by new clinical studies. Recent advances in understanding from such studies have led to refinement of the TDS hypothesis, highlighting the central role that deficient androgen production/action during fetal testis development, may play in the origin of downstream disorders.

Original language	English
Pages (from-to)	e33-e38
Journal	Fertility and Sterility
Volume	89
Issue number	2 Supplement
DOIs	https://doi.org/10.1016/j.fertnstert.2007.12.026
Publication status	Published - Feb 2008

Keywords

Testosterone
Sertoli cell
Leydig cell
fetal germ cells
cryptorchidism
hypospadias
low sperm counts
anogenital distance
compensated Leydig cell failure

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10.1016/j.fertnstert.2007.12.026

http://www.sciencedirect.com/science/article/pii/S0015028207043026

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title = "Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects",

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KW - Testosterone

KW - Sertoli cell

KW - Leydig cell

KW - fetal germ cells

KW - cryptorchidism

KW - hypospadias

KW - low sperm counts

KW - anogenital distance

KW - compensated Leydig cell failure

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SP - e33-e38

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JF - Fertility and Sterility

SN - 0015-0282

IS - 2 Supplement

ER -

Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects

Abstract

Keywords

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