Testicular Sertoli cell hormones in Differences in Sex Development

Angela K. Lucas-Herald; Rod T Mitchell

doi:10.3389/fendo.2022.919670

Testicular Sertoli cell hormones in Differences in Sex Development

Angela K. Lucas-Herald, Rod T Mitchell^*

^*Corresponding author for this work

MRC Centre for Reproductive Health

Research output: Contribution to journal › Article › peer-review

Abstract

The Sertoli cells of the testes play an essential role during gonadal development, in addition to supporting subsequent germ cell survival and spermatogenesis. Anti-Müllerian hormone (AMH) is a member of the TGF-β superfamily, which is secreted by immature Sertoli cells from the 8th week of fetal gestation. lnhibin B is a glycoprotein, which is produced by the Sertoli cells from early in fetal development. In people with a Difference or Disorder of Sex Development (DSD), these hormones may be useful to determine the presence of testicular tissue and potential for spermatogenesis. However, fetal Sertoli cell development and function is often dysregulated in DSD conditions and altered production of Sertoli cell hormones may be detected throughout the life course in these individuals. As such this review will consider the role of AMH and inhibin B in individuals with DSD.

Original language	English
Article number	919670
Journal	Frontiers in Endocrinology
Volume	13
DOIs	https://doi.org/10.3389/fendo.2022.919670
Publication status	Published - 14 Jul 2022

Keywords

AMH
inhibin B
testes
spermatogenesis
Sertoli cell

Access to Document

10.3389/fendo.2022.919670Licence: Creative Commons: Attribution (CC-BY)

Accepted ManuscriptAccepted author manuscript, 90 KBLicence: Creative Commons: Attribution (CC-BY)
fendo-13-919670Final published version, 537 KBLicence: Creative Commons: Attribution (CC-BY)

1 Finished
1 Active

Protecting spermatogonial stem cells from chemotherapy-induced damage for fertility preservation in childhood cancer
Carragher, N.
MRC
1/05/19 → 30/04/23
Project: Research
MRC Centre for Reproductive Health at the University of Edinburgh
Pollard, J.
MRC
12/09/16 → 11/09/22
Project: Research

Cite this

@article{2b7d7c1595ac4308a31e7d5ce0b42a4d,

title = "Testicular Sertoli cell hormones in Differences in Sex Development",

abstract = "The Sertoli cells of the testes play an essential role during gonadal development, in addition to supporting subsequent germ cell survival and spermatogenesis. Anti-M{\"u}llerian hormone (AMH) is a member of the TGF-β superfamily, which is secreted by immature Sertoli cells from the 8th week of fetal gestation. lnhibin B is a glycoprotein, which is produced by the Sertoli cells from early in fetal development. In people with a Difference or Disorder of Sex Development (DSD), these hormones may be useful to determine the presence of testicular tissue and potential for spermatogenesis. However, fetal Sertoli cell development and function is often dysregulated in DSD conditions and altered production of Sertoli cell hormones may be detected throughout the life course in these individuals. As such this review will consider the role of AMH and inhibin B in individuals with DSD.",

keywords = "AMH, inhibin B, testes, spermatogenesis, Sertoli cell",

author = "Lucas-Herald, {Angela K.} and Mitchell, {Rod T}",

note = "Funding Information: AL-H is funded by the NES/CSO Joint Clinical Lectureship scheme. RM is supported by UKRI Future Leaders Fellowship (MR/S017151/1). The MRC Centre for Reproductive Health at the University of Edinburgh is supported by MRC (MR/N022556/1). Publisher Copyright: Copyright {\textcopyright} 2022 Lucas-Herald and Mitchell.",

year = "2022",

month = jul,

day = "14",

doi = "10.3389/fendo.2022.919670",

language = "English",

volume = "13",

journal = "Frontiers in Endocrinology",

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T1 - Testicular Sertoli cell hormones in Differences in Sex Development

AU - Lucas-Herald, Angela K.

AU - Mitchell, Rod T

N1 - Funding Information: AL-H is funded by the NES/CSO Joint Clinical Lectureship scheme. RM is supported by UKRI Future Leaders Fellowship (MR/S017151/1). The MRC Centre for Reproductive Health at the University of Edinburgh is supported by MRC (MR/N022556/1). Publisher Copyright: Copyright © 2022 Lucas-Herald and Mitchell.

PY - 2022/7/14

Y1 - 2022/7/14

N2 - The Sertoli cells of the testes play an essential role during gonadal development, in addition to supporting subsequent germ cell survival and spermatogenesis. Anti-Müllerian hormone (AMH) is a member of the TGF-β superfamily, which is secreted by immature Sertoli cells from the 8th week of fetal gestation. lnhibin B is a glycoprotein, which is produced by the Sertoli cells from early in fetal development. In people with a Difference or Disorder of Sex Development (DSD), these hormones may be useful to determine the presence of testicular tissue and potential for spermatogenesis. However, fetal Sertoli cell development and function is often dysregulated in DSD conditions and altered production of Sertoli cell hormones may be detected throughout the life course in these individuals. As such this review will consider the role of AMH and inhibin B in individuals with DSD.

AB - The Sertoli cells of the testes play an essential role during gonadal development, in addition to supporting subsequent germ cell survival and spermatogenesis. Anti-Müllerian hormone (AMH) is a member of the TGF-β superfamily, which is secreted by immature Sertoli cells from the 8th week of fetal gestation. lnhibin B is a glycoprotein, which is produced by the Sertoli cells from early in fetal development. In people with a Difference or Disorder of Sex Development (DSD), these hormones may be useful to determine the presence of testicular tissue and potential for spermatogenesis. However, fetal Sertoli cell development and function is often dysregulated in DSD conditions and altered production of Sertoli cell hormones may be detected throughout the life course in these individuals. As such this review will consider the role of AMH and inhibin B in individuals with DSD.

KW - AMH

KW - inhibin B

KW - testes

KW - spermatogenesis

KW - Sertoli cell

U2 - 10.3389/fendo.2022.919670

DO - 10.3389/fendo.2022.919670

M3 - Article

VL - 13

JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

SN - 1664-2392

M1 - 919670

ER -

Testicular Sertoli cell hormones in Differences in Sex Development

Abstract

Keywords

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Projects

Protecting spermatogonial stem cells from chemotherapy-induced damage for fertility preservation in childhood cancer

MRC Centre for Reproductive Health at the University of Edinburgh

Cite this