Testing for the dual-route cascade reading model in the brain: an fMRI effective connectivity account of an efficient reading style

Jonathan Levy, Cyril Pernet, Sébastien Treserras, Kader Boulanouar, Florent Aubry, Jean-François Démonet, Pierre Celsis

Research output: Contribution to journalArticlepeer-review

Abstract

Neuropsychological data about the forms of acquired reading impairment provide a strong basis for the theoretical framework of the dual-route cascade (DRC) model which is predictive of reading performance. However, lesions are often extensive and heterogeneous, thus making it difficult to establish precise functional anatomical correlates. Here, we provide a connective neural account in the aim of accommodating the main principles of the DRC framework and to make predictions on reading skill. We located prominent reading areas using fMRI and applied structural equation modeling to pinpoint distinct neural pathways. Functionality of regions together with neural network dissociations between words and pseudowords corroborate the existing neuroanatomical view on the DRC and provide a novel outlook on the sub-regions involved. In a similar vein, congruent (or incongruent) reliance of pathways, that is reliance on the word (or pseudoword) pathway during word reading and on the pseudoword (or word) pathway during pseudoword reading predicted good (or poor) reading performance as assessed by out-of-magnet reading tests. Finally, inter-individual analysis unraveled an efficient reading style mirroring pathway reliance as a function of the fingerprint of the stimulus to be read, suggesting an optimal pattern of cerebral information trafficking which leads to high reading performance.
Original languageEnglish
Pages (from-to)e6675
JournalPLoS ONE
Volume4
Issue number8
DOIs
Publication statusPublished - 2009

Keywords

  • Brain
  • Humans
  • Magnetic Resonance Imaging
  • Models, Biological
  • Neuropsychological Tests
  • Reading

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