Testing replication of a 5-SNP set for general cognitive ability in six population samples

M. Luciano; P. A. Lind; I. J. Deary; A. Payton; D. Posthuma; L. M. Butcher; Z. Bochdanovits; L. J. Whalley; P. M. Visscher; Sarah Harris; T. J. C. Polderman; O. S. P. Davis; Margaret. J. Wright; John Starr; E. J. C. de Geus; T. C. Bates; Grant. W. Montgomery; D. I. Boomsma; Nicholas. G. Martin; R. Plomin

doi:10.1038/ejhg.2008.100

Testing replication of a 5-SNP set for general cognitive ability in six population samples

M. Luciano, P. A. Lind, I. J. Deary, A. Payton, D. Posthuma, L. M. Butcher, Z. Bochdanovits, L. J. Whalley, P. M. Visscher, Sarah Harris, T. J. C. Polderman, O. S. P. Davis, Margaret. J. Wright, John Starr, E. J. C. de Geus, T. C. Bates, Grant. W. Montgomery, D. I. Boomsma, Nicholas. G. Martin, R. Plomin

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Abstract

A 5-single nucleotide polymorphism (SNP) set has been associated with general cognitive ability in 5000 7-year-old children from the Twins Early Development Study (TEDS). Four of these SNPs were identified through a 10 K microarray analysis and one was identified through a targeted analysis of brain-expressed genes. The present study tested this association with general cognitive ability in six population samples of varying size and age from Australia, the UK (Scotland and England) and the Netherlands. Results from the largest sample (N=1310) approached significance (P=0.06) in the direction of the original finding, but results from the other samples (N=205-758) were mixed. A meta-analysis of the results - allowing for effect size heterogeneity between samples - yielded a non-significant correlation (r = -0.01, P=0.57), indicating that this SNP set was not associated with general cognitive ability in the populations studied. European Journal of Human Genetics (2008) 16, 1388-1395; doi:10.1038/ejhg.2008.100; published online 21 May 2008

Original language	English
Pages (from-to)	1388-1395
Number of pages	8
Journal	European Journal of Human Genetics
Volume	16
DOIs	https://doi.org/10.1038/ejhg.2008.100
Publication status	Published - 21 May 2008

Keywords / Materials (for Non-textual outputs)

snp set

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10.1038/ejhg.2008.100

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Luciano, M., Lind, P. A., Deary, I. J., Payton, A., Posthuma, D., Butcher, L. M., Bochdanovits, Z., Whalley, L. J., Visscher, P. M., Harris, S., Polderman, T. J. C., Davis, O. S. P., Wright, M. J., Starr, J., de Geus, E. J. C., Bates, T. C., Montgomery, G. W., Boomsma, D. I., Martin, N. G., & Plomin, R. (2008). Testing replication of a 5-SNP set for general cognitive ability in six population samples. European Journal of Human Genetics, 16, 1388-1395. https://doi.org/10.1038/ejhg.2008.100

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abstract = "A 5-single nucleotide polymorphism (SNP) set has been associated with general cognitive ability in 5000 7-year-old children from the Twins Early Development Study (TEDS). Four of these SNPs were identified through a 10 K microarray analysis and one was identified through a targeted analysis of brain-expressed genes. The present study tested this association with general cognitive ability in six population samples of varying size and age from Australia, the UK (Scotland and England) and the Netherlands. Results from the largest sample (N=1310) approached significance (P=0.06) in the direction of the original finding, but results from the other samples (N=205-758) were mixed. A meta-analysis of the results - allowing for effect size heterogeneity between samples - yielded a non-significant correlation (r = -0.01, P=0.57), indicating that this SNP set was not associated with general cognitive ability in the populations studied. European Journal of Human Genetics (2008) 16, 1388-1395; doi:10.1038/ejhg.2008.100; published online 21 May 2008",

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author = "M. Luciano and Lind, {P. A.} and Deary, {I. J.} and A. Payton and D. Posthuma and Butcher, {L. M.} and Z. Bochdanovits and Whalley, {L. J.} and Visscher, {P. M.} and Sarah Harris and Polderman, {T. J. C.} and Davis, {O. S. P.} and Wright, {Margaret. J.} and John Starr and {de Geus}, {E. J. C.} and Bates, {T. C.} and Montgomery, {Grant. W.} and Boomsma, {D. I.} and Martin, {Nicholas. G.} and R. Plomin",

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doi = "10.1038/ejhg.2008.100",

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Luciano, M, Lind, PA, Deary, IJ, Payton, A, Posthuma, D, Butcher, LM, Bochdanovits, Z, Whalley, LJ, Visscher, PM, Harris, S, Polderman, TJC, Davis, OSP, Wright, MJ, Starr, J, de Geus, EJC, Bates, TC, Montgomery, GW, Boomsma, DI, Martin, NG & Plomin, R 2008, 'Testing replication of a 5-SNP set for general cognitive ability in six population samples', European Journal of Human Genetics, vol. 16, pp. 1388-1395. https://doi.org/10.1038/ejhg.2008.100

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AU - Luciano, M.

AU - Lind, P. A.

AU - Deary, I. J.

AU - Payton, A.

AU - Posthuma, D.

AU - Butcher, L. M.

AU - Bochdanovits, Z.

AU - Whalley, L. J.

AU - Visscher, P. M.

AU - Harris, Sarah

AU - Polderman, T. J. C.

AU - Davis, O. S. P.

AU - Wright, Margaret. J.

AU - Starr, John

AU - de Geus, E. J. C.

AU - Bates, T. C.

AU - Montgomery, Grant. W.

AU - Boomsma, D. I.

AU - Martin, Nicholas. G.

AU - Plomin, R.

PY - 2008/5/21

Y1 - 2008/5/21

N2 - A 5-single nucleotide polymorphism (SNP) set has been associated with general cognitive ability in 5000 7-year-old children from the Twins Early Development Study (TEDS). Four of these SNPs were identified through a 10 K microarray analysis and one was identified through a targeted analysis of brain-expressed genes. The present study tested this association with general cognitive ability in six population samples of varying size and age from Australia, the UK (Scotland and England) and the Netherlands. Results from the largest sample (N=1310) approached significance (P=0.06) in the direction of the original finding, but results from the other samples (N=205-758) were mixed. A meta-analysis of the results - allowing for effect size heterogeneity between samples - yielded a non-significant correlation (r = -0.01, P=0.57), indicating that this SNP set was not associated with general cognitive ability in the populations studied. European Journal of Human Genetics (2008) 16, 1388-1395; doi:10.1038/ejhg.2008.100; published online 21 May 2008

AB - A 5-single nucleotide polymorphism (SNP) set has been associated with general cognitive ability in 5000 7-year-old children from the Twins Early Development Study (TEDS). Four of these SNPs were identified through a 10 K microarray analysis and one was identified through a targeted analysis of brain-expressed genes. The present study tested this association with general cognitive ability in six population samples of varying size and age from Australia, the UK (Scotland and England) and the Netherlands. Results from the largest sample (N=1310) approached significance (P=0.06) in the direction of the original finding, but results from the other samples (N=205-758) were mixed. A meta-analysis of the results - allowing for effect size heterogeneity between samples - yielded a non-significant correlation (r = -0.01, P=0.57), indicating that this SNP set was not associated with general cognitive ability in the populations studied. European Journal of Human Genetics (2008) 16, 1388-1395; doi:10.1038/ejhg.2008.100; published online 21 May 2008

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U2 - 10.1038/ejhg.2008.100

DO - 10.1038/ejhg.2008.100

M3 - Article

SN - 1018-4813

VL - 16

SP - 1388

EP - 1395

JO - European Journal of Human Genetics

JF - European Journal of Human Genetics

ER -

Testing replication of a 5-SNP set for general cognitive ability in six population samples

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Age-related cognitive changes in healthy humans: influences from genetic variation in genes related to oxidative stress

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Testing replication of a 5-SNP set for general cognitive ability in six population samples

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Age-related cognitive changes in healthy humans: influences from genetic variation in genes related to oxidative stress

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