Testing the extent of sequence similarity among viroids, satellite RNAs, and hepatitis delta virus

G M Jenkins, C H Woelk, A Rambaut, E C Holmes

Research output: Contribution to journalLetterpeer-review

Abstract / Description of output

A Monte Carlo method was used to test the extent of sequence similarity among viroids, satellite RNAs, and hepatitis delta virus. This analysis revealed that there is insufficient sequence similarity among these pathogens to support the hypothesis that they have a common evolutionary origin. Furthermore, while definite patterns of sequence similarity were observed among some viroids, there was a clear lack of overall similarity, indicating that a monophyletic origin for even this group cannot be reliably supported from sequence data alone.

Original languageEnglish
Pages (from-to)98-102
Number of pages5
JournalJournal of molecular evolution
Volume50
Issue number1
Publication statusPublished - Jan 2000

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