Tetrahydrobenzothiophene carboxamides: Beyond the kinase domain and into the fatty acid realm

Sabin Llona-Minguez*, Shabnam Fayezi, Alireza Alihemmati, Jordi Juárez-Jiménez, F. Javier Piedrafita, Thomas Helleday

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

A series of tetrahydrobenzothiophene carboxamides, inspired by structural features present in kinase and SCD1 inhibitors, are presented here. Prototype compound 8 (MMDD13) modulates fatty acid elongase and desaturase indexes, lipid accumulation, while preserving kinase inhibitory activity. This chemotype represents a stepping stone towards chemical probes to study the consequences of lipid metabolism modulation through non-redundant pathways.

Original languageEnglish
Pages (from-to)4462-4466
Number of pages5
JournalBioorganic & Medicinal Chemistry Letters
Volume27
Issue number18
Early online date5 Aug 2017
DOIs
Publication statusE-pub ahead of print - 5 Aug 2017

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