Tetrazine-Responsive Self-immolative Linkers

Kevin Neumann; Sarthak Jain; Alessia Gambardella; Sarah E. Walker; Elsa Valero; Annamaria Lilienkampf; Mark Bradley

doi:10.1002/cbic.201600560

Tetrazine-Responsive Self-immolative Linkers

Kevin Neumann, Sarthak Jain, Alessia Gambardella, Sarah E. Walker, Elsa Valero, Annamaria Lilienkampf, Mark Bradley

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Molecules that undergo activation or modulation following the addition of benign external small-molecule chemical stimuli have numerous applications. Here, we report the highly efficient “decaging” of a variety of moieties by activation of a “self-immolative” linker, by application of water-soluble and stable tetrazine, including the controlled delivery of doxorubicin in a cellular context.

Original language	English
Pages (from-to)	91-95
Journal	ChemBioChem
Volume	18
Issue number	1
Early online date	16 Dec 2016
DOIs	https://doi.org/10.1002/cbic.201600560
Publication status	Published - 3 Jan 2017

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10.1002/cbic.201600560

20161026 Bradley ChemBioChem_Neumann_SubmittedAccepted author manuscript, 1.29 MB

http://doi.wiley.com/10.1002/cbic.201600560

ADREEM: Adding Another Dimension Arrays of 3D Bio-Responsive materials
Bradley, M.
EU government bodies
1/11/14 → 31/10/19
Project: Research

Cite this

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title = "Tetrazine-Responsive Self-immolative Linkers",

abstract = "Molecules that undergo activation or modulation following the addition of benign external small-molecule chemical stimuli have numerous applications. Here, we report the highly efficient “decaging” of a variety of moieties by activation of a “self-immolative” linker, by application of water-soluble and stable tetrazine, including the controlled delivery of doxorubicin in a cellular context.",

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AU - Jain, Sarthak

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AU - Walker, Sarah E.

AU - Valero, Elsa

AU - Lilienkampf, Annamaria

AU - Bradley, Mark

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Tetrazine-Responsive Self-immolative Linkers

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ADREEM: Adding Another Dimension Arrays of 3D Bio-Responsive materials

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