Textural Characterization on Regions of Interest: A Useful Tool for the Study of Small Vessel Disease

Linda Viksne, Maria Valdes Hernandez, Katie Hoban, Anna K. Heye, Victor Gonzalez-Castro, Joanna Wardlaw

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract / Description of output

We propose a framework for investigating the properties of apparently normal
tissues on brain structural magnetic resonance images of patients with small vessel disease (SVD). It involves the extraction of textural features in regions of interest (ROIs) obtained from an anatomically-relevant template, combined with statistical analysis that considers the relative distribution of SVD markers (e.g. microbleeds, perivascular spaces and white matter hyperintensities) with respect to the ROIs’ textural characteristics in arterial territories derived from another template. We apply this approach to data from 42 patients from a study of mild stroke to investigate whether or not normal tissues in different brain regions are homogeneous regardless of the presence of specific SVD markers and varieties in the manifestations of the pathology (stroke lesion in different arterial territories). Our results suggest that this is not the case: that normal tissues are heterogeneous and that local variations (represented by the entropy) are associated with SVD markers, in agreement with clinical reports.
Original languageEnglish
Title of host publicationProceedings of the 19th Conference on Medical Image Understanding and Analysis
Number of pages6
Publication statusPublished - 2015
EventMedical Image Understanding and Analysis 2015 - Lincoln, United Kingdom
Duration: 15 Jul 201517 Jul 2015


ConferenceMedical Image Understanding and Analysis 2015
Country/TerritoryUnited Kingdom


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