TFF3 induced Fos protein expression in the magnocellular oxytocin neurons of the hypothalamus

Abigail Derbyshire, Mike Ludwig

Research output: Contribution to journalArticlepeer-review

Abstract

TFF3 is synthesized in magnocellular oxytocin neurons of the supraoptic (SON) and paraventricular nuclei (PVN) of the rat and human hypothalamus. Here we investigated whether intracerebroventricular (i.c.v.) injection of TFF3 stimulates oxytocin release into the blood and activates Fos protein immunoreactivity in oxytocin neurons of the SON and PVN in rats. The results show that plasma oxytocin concentrations were not altered after i.c.v. injection of TFF3 or vehicle. Fos protein expression was significantly increased in both the SON and PVN after TFF3 injections and double labeling studies showed that the Fos signal was predominantly in oxytocin neurons.

Original languageEnglish
Pages (from-to)833-8
Number of pages6
JournalPeptides
Volume25
Issue number5
DOIs
Publication statusPublished - May 2004

Keywords

  • Animals
  • Female
  • Genes, fos
  • Hypothalamus
  • Neurons
  • Neuropeptides
  • Oxytocin
  • Paraventricular Hypothalamic Nucleus
  • Rats
  • Rats, Sprague-Dawley
  • Supraoptic Nucleus

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