Abstract / Description of output
The contribution of transforming growth factor beta (TGF-beta) signaling to breast cancer has been studied for more than two decades. In an early phase TGF-beta may act as a tumour suppressor, while later, when cells have become resistant to its anti-mitogenic effects, the role of TGF-beta switches towards malignant conversion and progression. TGF-beta stimulates cell invasion and modifies the microenvironment to the advantage of cancer cells. Studies have shown that TGF-beta promotes bone and lung metastasis via different mechanisms. The therapeutic strategies to target the TGF-beta pathway in breast cancer are becoming increasingly clear. This review will focus on the role TGF-beta in breast cancer invasion and metastasis.
| Original language | English |
|---|---|
| Pages (from-to) | 97-108 |
| Number of pages | 12 |
| Journal | Journal of Mammary Gland Biology and Neoplasia |
| Volume | 16 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jun 2011 |
Keywords / Materials (for Non-textual outputs)
- EMT
- Invasion
- Metastasis
- Microenvironment
- Stroma
- TGF-beta
- GROWTH-FACTOR-BETA
- EPITHELIAL-MESENCHYMAL TRANSITION
- HORMONE-RELATED PROTEIN
- MAMMARY-CARCINOMA CELLS
- TUMOR-CELLS
- MORPHOGENETIC PROTEIN-7
- 3-DIMENSIONAL CULTURE
- LUNG METASTASIS
- PROGRESSION
- MICROENVIRONMENT