TGF-beta Signaling in Breast Cancer Cell Invasion and Bone Metastasis

Yvette Drabsch, Peter ten Dijke*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The contribution of transforming growth factor beta (TGF-beta) signaling to breast cancer has been studied for more than two decades. In an early phase TGF-beta may act as a tumour suppressor, while later, when cells have become resistant to its anti-mitogenic effects, the role of TGF-beta switches towards malignant conversion and progression. TGF-beta stimulates cell invasion and modifies the microenvironment to the advantage of cancer cells. Studies have shown that TGF-beta promotes bone and lung metastasis via different mechanisms. The therapeutic strategies to target the TGF-beta pathway in breast cancer are becoming increasingly clear. This review will focus on the role TGF-beta in breast cancer invasion and metastasis.

Original languageEnglish
Pages (from-to)97-108
Number of pages12
JournalJournal of Mammary Gland Biology and Neoplasia
Volume16
Issue number2
DOIs
Publication statusPublished - Jun 2011

Keywords

  • EMT
  • Invasion
  • Metastasis
  • Microenvironment
  • Stroma
  • TGF-beta
  • GROWTH-FACTOR-BETA
  • EPITHELIAL-MESENCHYMAL TRANSITION
  • HORMONE-RELATED PROTEIN
  • MAMMARY-CARCINOMA CELLS
  • TUMOR-CELLS
  • MORPHOGENETIC PROTEIN-7
  • 3-DIMENSIONAL CULTURE
  • LUNG METASTASIS
  • PROGRESSION
  • MICROENVIRONMENT

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