TGF-beta signalling and its role in cancer progression and metastasis

Yvette Drabsch; Peter ten Dijke

doi:10.1007/s10555-012-9375-7

TGF-beta signalling and its role in cancer progression and metastasis

Yvette Drabsch^*, Peter ten Dijke

^*Corresponding author for this work

Research output: Contribution to journal › Literature review › peer-review

Abstract

The transforming growth factor-beta (TGF-beta) system signals via protein kinase receptors and SMAD mediators to regulate a large number of biological processes. Alterations of the TGF-beta signalling pathway are implicated in human cancer. Prior to tumour initiation and early during progression, TGF-beta acts as a tumour suppressor; however, at later stages, it is often a tumour promoter. Knowledge about the mechanisms involved in TGF-beta signal transduction has allowed a better understanding of cancer progression, invasion, metastasis and epithelial-to-mesenchymal transition. Furthermore, several molecular targets with great potential in therapeutic interventions have been identified. This review discusses the TGF-beta signalling pathway, its involvement in cancer and current therapeutic approaches.

Original language	English
Pages (from-to)	553-568
Number of pages	16
Journal	Cancer and metastasis reviews
Volume	31
Issue number	3-4
DOIs	https://doi.org/10.1007/s10555-012-9375-7
Publication status	Published - Dec 2012

Keywords / Materials (for Non-textual outputs)

TGF-beta signalling
SMAD
Cancer
Epithelial to mesenchymal transition
TRANSFORMING-GROWTH-FACTOR
EPITHELIAL-MESENCHYMAL TRANSITION
INVASIVE BREAST-CANCER
BONE MORPHOGENETIC PROTEIN
COLORECTAL-CANCER
IN-VIVO
COLON-CANCER
C-MYC
TUMOR-SUPPRESSOR
DRUG-RESISTANCE

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10.1007/s10555-012-9375-7

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@article{9440b6498ce64258aa61bf886d551604,

title = "TGF-beta signalling and its role in cancer progression and metastasis",

abstract = "The transforming growth factor-beta (TGF-beta) system signals via protein kinase receptors and SMAD mediators to regulate a large number of biological processes. Alterations of the TGF-beta signalling pathway are implicated in human cancer. Prior to tumour initiation and early during progression, TGF-beta acts as a tumour suppressor; however, at later stages, it is often a tumour promoter. Knowledge about the mechanisms involved in TGF-beta signal transduction has allowed a better understanding of cancer progression, invasion, metastasis and epithelial-to-mesenchymal transition. Furthermore, several molecular targets with great potential in therapeutic interventions have been identified. This review discusses the TGF-beta signalling pathway, its involvement in cancer and current therapeutic approaches.",

keywords = "TGF-beta signalling, SMAD, Cancer, Epithelial to mesenchymal transition, TRANSFORMING-GROWTH-FACTOR, EPITHELIAL-MESENCHYMAL TRANSITION, INVASIVE BREAST-CANCER, BONE MORPHOGENETIC PROTEIN, COLORECTAL-CANCER, IN-VIVO, COLON-CANCER, C-MYC, TUMOR-SUPPRESSOR, DRUG-RESISTANCE",

author = "Yvette Drabsch and \{ten Dijke\}, Peter",

year = "2012",

month = dec,

doi = "10.1007/s10555-012-9375-7",

language = "English",

volume = "31",

pages = "553--568",

journal = "Cancer and metastasis reviews",

issn = "0167-7659",

publisher = "Springer",

number = "3-4",

}

TY - JOUR

T1 - TGF-beta signalling and its role in cancer progression and metastasis

AU - Drabsch, Yvette

AU - ten Dijke, Peter

PY - 2012/12

Y1 - 2012/12

N2 - The transforming growth factor-beta (TGF-beta) system signals via protein kinase receptors and SMAD mediators to regulate a large number of biological processes. Alterations of the TGF-beta signalling pathway are implicated in human cancer. Prior to tumour initiation and early during progression, TGF-beta acts as a tumour suppressor; however, at later stages, it is often a tumour promoter. Knowledge about the mechanisms involved in TGF-beta signal transduction has allowed a better understanding of cancer progression, invasion, metastasis and epithelial-to-mesenchymal transition. Furthermore, several molecular targets with great potential in therapeutic interventions have been identified. This review discusses the TGF-beta signalling pathway, its involvement in cancer and current therapeutic approaches.

AB - The transforming growth factor-beta (TGF-beta) system signals via protein kinase receptors and SMAD mediators to regulate a large number of biological processes. Alterations of the TGF-beta signalling pathway are implicated in human cancer. Prior to tumour initiation and early during progression, TGF-beta acts as a tumour suppressor; however, at later stages, it is often a tumour promoter. Knowledge about the mechanisms involved in TGF-beta signal transduction has allowed a better understanding of cancer progression, invasion, metastasis and epithelial-to-mesenchymal transition. Furthermore, several molecular targets with great potential in therapeutic interventions have been identified. This review discusses the TGF-beta signalling pathway, its involvement in cancer and current therapeutic approaches.

KW - TGF-beta signalling

KW - SMAD

KW - Cancer

KW - Epithelial to mesenchymal transition

KW - TRANSFORMING-GROWTH-FACTOR

KW - EPITHELIAL-MESENCHYMAL TRANSITION

KW - INVASIVE BREAST-CANCER

KW - BONE MORPHOGENETIC PROTEIN

KW - COLORECTAL-CANCER

KW - IN-VIVO

KW - COLON-CANCER

KW - C-MYC

KW - TUMOR-SUPPRESSOR

KW - DRUG-RESISTANCE

U2 - 10.1007/s10555-012-9375-7

DO - 10.1007/s10555-012-9375-7

M3 - Literature review

SN - 0167-7659

VL - 31

SP - 553

EP - 568

JO - Cancer and metastasis reviews

JF - Cancer and metastasis reviews

IS - 3-4

ER -

TGF-beta signalling and its role in cancer progression and metastasis

Abstract

Keywords / Materials (for Non-textual outputs)

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