Th1-Th2: reliable paradigm or dangerous dogma?

Research output: Contribution to journalArticlepeer-review

Abstract

The identification of crossregulating T helper (Th) cells has revolutionized current understanding of the immune response to infection. While paying tribute to this revolution. Judith Allen and Rick Maizels argue that the paradigm can be dangerously oversimplified and that the interaction between host and pathogen cannot always be addressed in the context of Th1 and Th2 cells.

Original languageEnglish
Pages (from-to)387-392
Number of pages6
JournalImmunology today
Volume18
Issue number8
Publication statusPublished - Aug 1997

Keywords

  • T-CELL SUBSET
  • INTERFERON-GAMMA
  • LEISHMANIA-MAJOR
  • CUTANEOUS LEISHMANIASIS
  • PROTECTIVE IMMUNITY
  • VISCERAL LEISHMANIASIS
  • MONOCLONAL-ANTIBODY
  • PLASMODIUM-CHABAUDI
  • DEPENDENT MECHANISM
  • SCHISTOSOMA-MANSONI

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