The 2014 International Workshop on Alport Syndrome

Jeffrey H Miner, Colin Baigent, Frances Flinter, Oliver Gross, Parminder Judge, Clifford E Kashtan, Sharon Lagas, Judith Savige, Dave Blatt, Jie Ding, Daniel P Gale, Julian P Midgley, Sue Povey, Marco Prunotto, Daniel Renault, Jules Skelding, A Neil Turner, Susie Gear, A Neil Turner

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Alport syndrome, historically referred to as hereditary glomerulonephritis with sensorineural deafness and anterior lenticonus, is a genetic disease of collagen α3α4α5(IV) resulting in renal failure. The collagen α3α4α5(IV) heterotrimer forms a network that is a major component of the kidney glomerular basement membrane (GBM) and basement membranes in the cochlea and eye. Alport syndrome, estimated to affect 1 in 5000-10,000 individuals, is caused by mutations in any one of the three genes that encode the α chain components of the collagen α3α4α5(IV) heterotrimer: COL4A3, COL4A4, and COL4A5. Although angiotensin-converting enzyme inhibition is effective in Alport syndrome patients for slowing progression to end-stage renal disease, it is neither a cure nor an adequate long-term protector. The 2014 International Workshop on Alport Syndrome, held in Oxford, UK, from January 3-5, was organized by individuals and families living with Alport syndrome, in concert with international experts in the clinical, genetic, and basic science aspects of the disease. Stakeholders from diverse communities-patient families, physicians, geneticists, researchers, Pharma, and funding organizations-were brought together so that they could meet and learn from each other and establish strategies and collaborations for the future, with the overall aim of discovering much needed new treatments to prolong kidney function.

Original languageEnglish
Pages (from-to)679-84
Number of pages6
JournalKidney International
Issue number4
Publication statusPublished - Oct 2014


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