The 3D Genome: EZH2 Comes into the Fold

Gerard L Brien, Adrian P Bracken

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

EZH2 is an oncogene in non-Hodgkin lymphoma. Understanding the underlying pathogenic mechanisms will be essential to improve treatments for patients with EZH2 mutant lymphomas. Recently Donaldson-Collier and colleagues (Nat. Genet. 2019; published online January 28, examined the effects of mutant EZH2 on the 3D architecture of the lymphoma genome, highlighting the potential relevance of chromatin folding dynamics.

Original languageEnglish
Pages (from-to)362-365
Number of pages4
JournalTrends in Molecular Medicine
Issue number5
Publication statusPublished - May 2019

Keywords / Materials (for Non-textual outputs)

  • Chromatin/genetics
  • Enhancer of Zeste Homolog 2 Protein/genetics
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Genomics/methods
  • Humans
  • Lymphoma, Non-Hodgkin/genetics
  • Mutation


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