The 3D Genome: EZH2 Comes into the Fold

Gerard L Brien; Adrian P Bracken

doi:10.1016/j.molmed.2019.02.013

The 3D Genome: EZH2 Comes into the Fold

Gerard L Brien, Adrian P Bracken

Deanery of Molecular, Genetic and Population Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

EZH2 is an oncogene in non-Hodgkin lymphoma. Understanding the underlying pathogenic mechanisms will be essential to improve treatments for patients with EZH2 mutant lymphomas. Recently Donaldson-Collier and colleagues (Nat. Genet. 2019; published online January 28, https://doi.org/10.1038/s41588-018-0338-y) examined the effects of mutant EZH2 on the 3D architecture of the lymphoma genome, highlighting the potential relevance of chromatin folding dynamics.

Original language	English
Pages (from-to)	362-365
Number of pages	4
Journal	Trends in Molecular Medicine
Volume	25
Issue number	5
DOIs	https://doi.org/10.1016/j.molmed.2019.02.013
Publication status	Published - May 2019

Keywords / Materials (for Non-textual outputs)

Chromatin/genetics
Enhancer of Zeste Homolog 2 Protein/genetics
Genetic Predisposition to Disease
Genome-Wide Association Study
Genomics/methods
Humans
Lymphoma, Non-Hodgkin/genetics
Mutation

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10.1016/j.molmed.2019.02.013

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title = "The 3D Genome: EZH2 Comes into the Fold",

abstract = "EZH2 is an oncogene in non-Hodgkin lymphoma. Understanding the underlying pathogenic mechanisms will be essential to improve treatments for patients with EZH2 mutant lymphomas. Recently Donaldson-Collier and colleagues (Nat. Genet. 2019; published online January 28, https://doi.org/10.1038/s41588-018-0338-y) examined the effects of mutant EZH2 on the 3D architecture of the lymphoma genome, highlighting the potential relevance of chromatin folding dynamics.",

keywords = "Chromatin/genetics, Enhancer of Zeste Homolog 2 Protein/genetics, Genetic Predisposition to Disease, Genome-Wide Association Study, Genomics/methods, Humans, Lymphoma, Non-Hodgkin/genetics, Mutation",

author = "Brien, {Gerard L} and Bracken, {Adrian P}",

year = "2019",

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doi = "10.1016/j.molmed.2019.02.013",

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AU - Bracken, Adrian P

PY - 2019/5

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N2 - EZH2 is an oncogene in non-Hodgkin lymphoma. Understanding the underlying pathogenic mechanisms will be essential to improve treatments for patients with EZH2 mutant lymphomas. Recently Donaldson-Collier and colleagues (Nat. Genet. 2019; published online January 28, https://doi.org/10.1038/s41588-018-0338-y) examined the effects of mutant EZH2 on the 3D architecture of the lymphoma genome, highlighting the potential relevance of chromatin folding dynamics.

AB - EZH2 is an oncogene in non-Hodgkin lymphoma. Understanding the underlying pathogenic mechanisms will be essential to improve treatments for patients with EZH2 mutant lymphomas. Recently Donaldson-Collier and colleagues (Nat. Genet. 2019; published online January 28, https://doi.org/10.1038/s41588-018-0338-y) examined the effects of mutant EZH2 on the 3D architecture of the lymphoma genome, highlighting the potential relevance of chromatin folding dynamics.

KW - Chromatin/genetics

KW - Enhancer of Zeste Homolog 2 Protein/genetics

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Genomics/methods

KW - Humans

KW - Lymphoma, Non-Hodgkin/genetics

KW - Mutation

U2 - 10.1016/j.molmed.2019.02.013

DO - 10.1016/j.molmed.2019.02.013

M3 - Article

C2 - 30885427

SN - 1471-4914

VL - 25

SP - 362

EP - 365

JO - Trends in Molecular Medicine

JF - Trends in Molecular Medicine

IS - 5

ER -

The 3D Genome: EZH2 Comes into the Fold

Abstract

Keywords / Materials (for Non-textual outputs)

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