Abstract
Purpose of Review
We aimed to explore, through a conceptual model, how can we maximise the post intensive care unit (ICU) recovery of patients with intensive care unit-acquired weakness (ICU-AW)? The “6 Ps” were used to structure our research questions, what are the Predisposing (pre-ICU patient characteristics), Precipitating (ICU exposures) and Perpetuating (hinder recovery post-ICU recovery) risk factors for ICU-AW (Problem) and what Protective strategies and Proactive treatment can we adopt to improve muscle mass, strength and function of these patients?
Recent Findings
Examination of the relationship between pre-ICU patient characteristics with ICU-AW and post-ICU factors that prolong recovery are limited. Our understanding of the pathophysiology of the condition is improving, however, much of the biological mechanisms of ICU-AW and persistent weakness remain unknown. Investigation into the ICU-AW phenotype and prediction tools would be of great clinical utility. Further research on ICU-AW muscle biology and recovery may permit the application of precision and personalised medicine to therapeutic interventions.
Summary
A structured approach to clinical practice and future research to better understand the mechanism (Problem), and identify Predisposing, Precipitating and Perpetuating risk factors will advance the field in better managing ICU-AW through implementation of Protective strategies and Proactive multimodal treatments.
We aimed to explore, through a conceptual model, how can we maximise the post intensive care unit (ICU) recovery of patients with intensive care unit-acquired weakness (ICU-AW)? The “6 Ps” were used to structure our research questions, what are the Predisposing (pre-ICU patient characteristics), Precipitating (ICU exposures) and Perpetuating (hinder recovery post-ICU recovery) risk factors for ICU-AW (Problem) and what Protective strategies and Proactive treatment can we adopt to improve muscle mass, strength and function of these patients?
Recent Findings
Examination of the relationship between pre-ICU patient characteristics with ICU-AW and post-ICU factors that prolong recovery are limited. Our understanding of the pathophysiology of the condition is improving, however, much of the biological mechanisms of ICU-AW and persistent weakness remain unknown. Investigation into the ICU-AW phenotype and prediction tools would be of great clinical utility. Further research on ICU-AW muscle biology and recovery may permit the application of precision and personalised medicine to therapeutic interventions.
Summary
A structured approach to clinical practice and future research to better understand the mechanism (Problem), and identify Predisposing, Precipitating and Perpetuating risk factors will advance the field in better managing ICU-AW through implementation of Protective strategies and Proactive multimodal treatments.
| Original language | English |
|---|---|
| Pages (from-to) | 367-372 |
| Journal | Current Opinion in Clinical Nutrition and Metabolic Care |
| Volume | 23 |
| Issue number | 5 |
| Publication status | Published - 1 Sept 2020 |
