The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca2+ release channels

Antony Galione, A. Mark Evans, Jianjie Ma, John Parrington, Abdelilah Arredouani, Xiaotong Cheng, Michael X. Zhu

Research output: Contribution to journalArticlepeer-review

Abstract

In this review, we describe the background and implications of our recent discovery that two-pore channels (TPCs) comprise a novel class of calcium release channels gated by the intracellular messenger nicotinic acid adenine dinucleotide phosphate (NAADP). Their localisation to the endolysosomal system highlights a new function for these organelles as targets for NAADP-mediated Ca2+ mobilisation. In addition, we describe how TPCs may also trigger further Ca2+ release by coupling to the endoplasmic reticular stores through activation of IP3 receptors and ryanodine receptors.

Original languageEnglish
Pages (from-to)869-876
Number of pages8
JournalPflügers Archiv European Journal of Physiology
Volume458
Issue number5
DOIs
Publication statusPublished - Sep 2009

Keywords

  • Inositol 1,4,5-trisphosphate
  • Pancreatic β-cell - Endothelin
  • Cholecystokinin
  • Ca2+-induced Ca2+ release
  • Ion channel
  • Ca2+ mobilisation
  • Ca2+ stores
  • Calcium signalling
  • Calcium transient

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