The activation level of the TNF family receptor, Edar, determines cusp number and tooth number during tooth development

A S Tucker, D J Headon, J-M Courtney, P Overbeek, P T Sharpe

Research output: Contribution to journalArticlepeer-review

Abstract

Mutations in members of the ectodysplasin (TNF-related) signalling pathway, EDA, EDAR, and EDARADD in mice and humans produce an ectodermal dysplasia phenotype that includes missing teeth and smaller teeth with reduced cusps. Using the keratin 14 promoter to target expression of an activated form of Edar in transgenic mice, we show that expression of this transgene is able to rescue the tooth phenotype in Tabby (Eda) and Sleek (Edar) mutant mice. High levels of expression of the transgene in wild-type mice result in molar teeth with extra cusps, and in some cases supernumerary teeth, the opposite of the mutant phenotype. The level of activation of Edar thus determines cusp number and tooth number during tooth development.
Original languageEnglish
Pages (from-to)185-94
Number of pages10
JournalDevelopmental Biology
Volume268
Issue number1
DOIs
Publication statusPublished - 1 Apr 2004

Keywords

  • Animals
  • Base Sequence
  • DNA Primers
  • Dental Enamel
  • Edar Receptor
  • Humans
  • Membrane Proteins
  • Mice
  • Mice, Transgenic
  • Receptors, Ectodysplasin
  • Receptors, Tumor Necrosis Factor
  • Tooth

Fingerprint Dive into the research topics of 'The activation level of the TNF family receptor, Edar, determines cusp number and tooth number during tooth development'. Together they form a unique fingerprint.

Cite this