THE ACUTE INFARCTION RAMIPRIL EFFICACY (AIRE) STUDY - RATIONALE, DESIGN, ORGANIZATION, AND OUTCOME DEFINITIONS

AS HALL, C WINTER, SM BOGLE, AF MACKINTOSH, GD MURRAY, SG BALL

Research output: Contribution to journalArticlepeer-review

Abstract

The rationale, design, organization, and outcome definitions of the Acute Infarction Ramipril Efficacy (AIRE) Study are described prospectively. A total of 2,000 patients (1,000 per treatment group) will be recruited to this multicenter, multinational, double-blind, randomized, placebo-controlled study investigating the effect of oral treatment with ramipril (2.5 or 5 mg twice daily) on the total mortality of survivors of an acute myocardial infarction (AMI) with early clinical evidence of heart failure. Secondary outcomes of the study include progression to severe/resistant heart failure (at which time the patient will be withdrawn from the study treatment), reinfarction, and stroke. Treatment will be initiated in hospital between day 3 and day 10 following AMI, and follow-up continued for an average of 15 months and a minimum of 6 months. The study data will be analyzed on an intention-to-treat basis: a single formal interim analysis will be conducted after 175 deaths. An Independent Adjudicating Panel will act as the overall ethical supervisory body for the study and will retain the randomization code. An International Steering Committee will be responsible for the clinical definitions of the secondary study outcomes, and will regularly review progress of the study. We believe that early treatment with ramipril may reduce the total mortality of patients surviving an AMI with clinical evidence of heart failure.

Original languageEnglish
Pages (from-to)S105-S109
Number of pages5
JournalJournal of cardiovascular pharmacology
Volume18
Publication statusPublished - 1991
EventMEETING ON ACE ( ANGIOTENSIN-CONVERTING ENZYME ) INHIBITION - PRESENT AND FUTURE : THE ROLE OF RAMIPRIL - LONDON, United Kingdom
Duration: 12 Oct 199013 Oct 1990

Keywords

  • AIRE STUDY
  • ACE INHIBITOR
  • MYOCARDIAL INFARCTION
  • RAMIPRIL
  • SURVIVAL
  • ACUTE MYOCARDIAL-INFARCTION
  • LEFT-VENTRICULAR DILATION
  • HEART-FAILURE
  • CORONARY CIRCULATION
  • CAPTOPRIL
  • RECOVERY
  • STRATIFICATION
  • ARTERY
  • DEATHS

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