The added value of ordinal analysis in clinical trials: an example in traumatic brain injury

IMPACT (International Mission on Prognosis and Clinical Trial Design in Traumatic Brain Injury) Study Group, Bob Roozenbeek, Hester F Lingsma, Pablo Perel, Phil Edwards, Ian Roberts, Gordon D Murray, Andrew Ir Maas, Ewout W Steyerberg

Research output: Contribution to journalArticlepeer-review

Abstract

In clinical trials, ordinal outcome measures are often dichotomized into two categories. In traumatic brain injury (TBI) the 5-point Glasgow outcome scale (GOS) is collapsed into unfavourable versus favourable outcome. Simulation studies have shown that exploiting the ordinal nature of the GOS increases chances of detecting treatment effects. The objective of this study is to quantify the benefits of ordinal analysis in the real-life situation of a large TBI trial.
Original languageEnglish
Pages (from-to)R127
JournalCritical Care
Volume15
Issue number3
DOIs
Publication statusPublished - 17 May 2011

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