The added value of ordinal analysis in clinical trials: an example in traumatic brain injury

IMPACT (International Mission on Prognosis and Clinical Trial Design in Traumatic Brain Injury) Study Group; Bob Roozenbeek; Hester F Lingsma; Pablo Perel; Phil Edwards; Ian Roberts; Gordon D Murray; Andrew Ir Maas; Ewout W Steyerberg

doi:10.1186/cc10240

The added value of ordinal analysis in clinical trials: an example in traumatic brain injury

IMPACT (International Mission on Prognosis and Clinical Trial Design in Traumatic Brain Injury) Study Group, Bob Roozenbeek, Hester F Lingsma, Pablo Perel, Phil Edwards, Ian Roberts, Gordon D Murray, Andrew Ir Maas, Ewout W Steyerberg

School of Regeneration and Repair

Research output: Contribution to journal › Article › peer-review

Abstract

In clinical trials, ordinal outcome measures are often dichotomized into two categories. In traumatic brain injury (TBI) the 5-point Glasgow outcome scale (GOS) is collapsed into unfavourable versus favourable outcome. Simulation studies have shown that exploiting the ordinal nature of the GOS increases chances of detecting treatment effects. The objective of this study is to quantify the benefits of ordinal analysis in the real-life situation of a large TBI trial.

Original language	English
Pages (from-to)	R127
Journal	Critical Care
Volume	15
Issue number	3
DOIs	https://doi.org/10.1186/cc10240
Publication status	Published - 17 May 2011

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10.1186/cc10240

The added value of ordinal analysis in clinical trials an example in traumatic brain injury
© 2011 Roozenbeek et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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http://ccforum.com/content/15/3/R127

MRC HUB NETWORK WORK
Murray, G. (Principal Investigator)
MRC
1/01/09 → 31/08/15
Project: Research

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IMPACT (International Mission on Prognosis and Clinical Trial Design in Traumatic Brain Injury) Study Group, Roozenbeek, B., Lingsma, H. F., Perel, P., Edwards, P., Roberts, I., Murray, G. D., Maas, A. I., & Steyerberg, E. W. (2011). The added value of ordinal analysis in clinical trials: an example in traumatic brain injury. Critical Care, 15(3), R127. https://doi.org/10.1186/cc10240

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abstract = "In clinical trials, ordinal outcome measures are often dichotomized into two categories. In traumatic brain injury (TBI) the 5-point Glasgow outcome scale (GOS) is collapsed into unfavourable versus favourable outcome. Simulation studies have shown that exploiting the ordinal nature of the GOS increases chances of detecting treatment effects. The objective of this study is to quantify the benefits of ordinal analysis in the real-life situation of a large TBI trial.",

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IMPACT (International Mission on Prognosis and Clinical Trial Design in Traumatic Brain Injury) Study Group, Roozenbeek, B, Lingsma, HF, Perel, P, Edwards, P, Roberts, I, Murray, GD, Maas, AI & Steyerberg, EW 2011, 'The added value of ordinal analysis in clinical trials: an example in traumatic brain injury', Critical Care, vol. 15, no. 3, pp. R127. https://doi.org/10.1186/cc10240

The added value of ordinal analysis in clinical trials: an example in traumatic brain injury. / IMPACT (International Mission on Prognosis and Clinical Trial Design in Traumatic Brain Injury) Study Group; Roozenbeek, Bob; Lingsma, Hester F et al.
In: Critical Care, Vol. 15, No. 3, 17.05.2011, p. R127.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The added value of ordinal analysis in clinical trials

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AU - IMPACT (International Mission on Prognosis and Clinical Trial Design in Traumatic Brain Injury) Study Group

AU - Roozenbeek, Bob

AU - Lingsma, Hester F

AU - Perel, Pablo

AU - Edwards, Phil

AU - Roberts, Ian

AU - Murray, Gordon D

AU - Maas, Andrew Ir

AU - Steyerberg, Ewout W

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AB - In clinical trials, ordinal outcome measures are often dichotomized into two categories. In traumatic brain injury (TBI) the 5-point Glasgow outcome scale (GOS) is collapsed into unfavourable versus favourable outcome. Simulation studies have shown that exploiting the ordinal nature of the GOS increases chances of detecting treatment effects. The objective of this study is to quantify the benefits of ordinal analysis in the real-life situation of a large TBI trial.

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DO - 10.1186/cc10240

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SN - 1466-609X

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SP - R127

JO - Critical Care

JF - Critical Care

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ER -

The added value of ordinal analysis in clinical trials: an example in traumatic brain injury

Abstract

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