The Animal Trypanosomiases and their chemotherapy: a review

Federica Giordani, Liam Morrison, Tim Rowan, Harry P. de Koning, Michael P. Barrett

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Pathogenic animal trypanosomes affecting livestock have represented a major constraint to agricultural development in Africa for centuries, and their negative economic impact is increasing in South America and Asia. Chemotherapy and chemoprophylaxis represent the main means of control. However, research into new trypanocides has remained inadequate for decades, leading to a situation where the few compounds available are losing efficacy due to the emergence of drug-resistant parasites. In this review, we provide a comprehensive overview of the current options available for the treatment and prophylaxis of the animal trypanosomiases, with a special focus on the problem of resistance. The key issues surrounding the main economically important animal trypanosome species and the diseases they cause are also presented. As new investment becomes available to develop improved tools to control the animal trypanosomiases, we stress that efforts should be directed towards a better understanding of the biology of the relevant parasite species and strains, to identify new drug targets and interrogate resistance mechanisms.
Original languageEnglish
Pages (from-to)1862-1889
Number of pages28
JournalParasitology
Volume143
Issue number14
Early online date10 Oct 2016
DOIs
Publication statusPublished - Dec 2016

Keywords

  • Trypanosoma brucei
  • Trypanosoma congolense
  • Trypanosoma vivax
  • animal trypanosomiases
  • drug resistance
  • veterinary trypanocide

Fingerprint Dive into the research topics of 'The Animal Trypanosomiases and their chemotherapy: a review'. Together they form a unique fingerprint.

Cite this