The anomalous effects of biased mutation revisited: Mean-optimum deviation and apparent directional selection under stabilizing selection

Xu-Sheng Zhang, William G. Hill

Research output: Contribution to journalArticlepeer-review

Abstract

Empirical evidence indicates that the distribution of the effects of mutations on quantitative traits is not symmetric about zero. Under stabilizing selection in infinite populations with normally distributed mutant effects having a nonzero mean, Waxman and Peck showed that the deviation of the population mean from the optimum is expected to be small. We show by simulation that genetic drift, leptokurtosis of mutational effects, and pleiotropy can increase the mean-optimum deviation greatly, however, and that the apparent directional selection thereby caused can be substantial.

Original languageEnglish
Pages (from-to)1135-1141
Number of pages7
JournalGenetics
Volume179
Issue number2
DOIs
Publication statusPublished - Jun 2008

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