Projects per year
Abstract / Description of output
INTRODUCTION: The ease of imaging the retinal vasculature, and the evolving evidence suggesting this microvascular bed might reflect the cerebral microvasculature, presents an opportunity to investigate cerebrovascular disease and the contribution of microvascular disease to dementia with fundus camera imaging.
METHODS: A systematic review and meta-analysis was carried out to assess the measurement of retinal properties in dementia using fundus imaging.
RESULTS: Ten studies assessing retinal properties in dementia were included. Quantitative measurement revealed significant yet inconsistent pathologic changes in vessel caliber, tortuosity and fractal dimension. Retinopathy was more prevalent in dementia. No association of age-related macular degeneration with dementia was reported.
DISCUSSION: Inconsistent findings across studies provides tentative support for the application of fundus camera imaging as a means of identifying changes associated with dementia. The potential of fundus image analysis in differentiating between dementia subtypes should be investigated using larger well characterised samples. Future work should focus on refining and standardising methods and measurements.
METHODS: A systematic review and meta-analysis was carried out to assess the measurement of retinal properties in dementia using fundus imaging.
RESULTS: Ten studies assessing retinal properties in dementia were included. Quantitative measurement revealed significant yet inconsistent pathologic changes in vessel caliber, tortuosity and fractal dimension. Retinopathy was more prevalent in dementia. No association of age-related macular degeneration with dementia was reported.
DISCUSSION: Inconsistent findings across studies provides tentative support for the application of fundus camera imaging as a means of identifying changes associated with dementia. The potential of fundus image analysis in differentiating between dementia subtypes should be investigated using larger well characterised samples. Future work should focus on refining and standardising methods and measurements.
| Original language | English |
|---|---|
| Pages (from-to) | 91-107 |
| Journal | Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Volume | 6 |
| Early online date | 2 Dec 2016 |
| DOIs | |
| Publication status | Published - 2017 |
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Dive into the research topics of 'The application of retinal fundus camera imaging in dementia: a systematic review'. Together they form a unique fingerprint.Projects
- 2 Finished
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TEST Multi-modal retinal biomarkers for vascular dementia: developing enabling image analysis tools
30/04/15 → 28/08/18
Project: Research
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RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.
Deary, I., Gale, C., Holmes, M., Logie, P., Maclullich, A., Porteous, D., Seckl, J., Starr, J., Wardlaw, J. & Okely, J.
1/09/13 → 31/08/19
Project: Research
Profiles
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Tom MacGillivray
- Deanery of Clinical Sciences - Reader
Person: Academic: Research Active (Research Assistant)