The association between obesity and asthma: interactions between systemic and airway inflammation

Tim J T Sutherland, Jan O Cowan, Sarah Young, Ailsa Goulding, Andrea M Grant, Avis Williamson, Karen Brassett, G Peter Herbison, D Robin Taylor

Research output: Contribution to journalArticlepeer-review

Abstract

Both obesity and asthma are common conditions, and both are characterized by the presence of inflammation. Animal studies suggest that the development of airway hyperresponsiveness with antigen challenge is exaggerated with obesity. However, clear evidence for either an additive or a synergistic pathologic interaction between obesity and asthma is lacking in humans.
Original languageEnglish
Pages (from-to)469-75
Number of pages7
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume178
Issue number5
DOIs
Publication statusPublished - 1 Sep 2008

Keywords

  • Adult
  • Asthma
  • Biological Markers
  • Case-Control Studies
  • Comorbidity
  • Cytokines
  • Female
  • Humans
  • Inflammation
  • Middle Aged
  • New Zealand
  • Obesity

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