The association between retinal vessel morphology and retinal nerve fiber layer thickness in an elderly population

Michael E Grinton; Augustinus Laude; Tom MacGillivray; Ross Henderson; John M Starr; Ian J Deary; Peter Aspinall; Baljean Dhillon

doi:10.3928/15428877-20120802-03

The association between retinal vessel morphology and retinal nerve fiber layer thickness in an elderly population

Michael E Grinton, Augustinus Laude, Tom MacGillivray, Ross Henderson, John M Starr, Ian J Deary, Peter Aspinall, Baljean Dhillon

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

BACKGROUND AND OBJECTIVE: To investigate the relationship between retinal vessel morphology (branching coefficient, bifurcation angle, and fractal analysis) and retinal nerve fiber layer (RNFL) thickness in an elderly population.

PATIENTS AND METHODS: One hundred and one participants from the Lothian Birth Cohort 1936 (population of people all born in 1936) were studied. RNFL thickness measurements (using optical coherence tomography [OCT]) and digital retinal photographs were collected. The retinal images were analyzed using custom-designed software called the Vascular Assessment and Measurement Platform for Images of the Retina.

RESULTS: Greater deviation from the optimal arteriolar branching coefficient was associated with greater RNFL thickness (r = 0.249, P = .028). There was no significant association between RNFL thickness and the other retinal vessel morphology parameters.

CONCLUSION: RNFL thickness increased significantly with suboptimality of arteriole branching coefficient. These findings cannot be explained by our current understanding of OCT. OCT-based biomarker metrics require further study to better define retinal neurovascular imaging and anatomy.

Original language	English
Pages (from-to)	S61-6
Journal	Ophthalmic surgery, lasers & imaging
Volume	43
Issue number	6 Suppl
DOIs	https://doi.org/10.3928/15428877-20120802-03
Publication status	Published - 14 Aug 2012

Keywords / Materials (for Non-textual outputs)

Aged
Cohort Studies
Female
Humans
Image Processing, Computer-Assisted
Male
Nerve Fibers
Retina
Retinal Vessels
Tomography, Optical Coherence

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10.3928/15428877-20120802-03

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title = "The association between retinal vessel morphology and retinal nerve fiber layer thickness in an elderly population",

abstract = "BACKGROUND AND OBJECTIVE: To investigate the relationship between retinal vessel morphology (branching coefficient, bifurcation angle, and fractal analysis) and retinal nerve fiber layer (RNFL) thickness in an elderly population.PATIENTS AND METHODS: One hundred and one participants from the Lothian Birth Cohort 1936 (population of people all born in 1936) were studied. RNFL thickness measurements (using optical coherence tomography [OCT]) and digital retinal photographs were collected. The retinal images were analyzed using custom-designed software called the Vascular Assessment and Measurement Platform for Images of the Retina.RESULTS: Greater deviation from the optimal arteriolar branching coefficient was associated with greater RNFL thickness (r = 0.249, P = .028). There was no significant association between RNFL thickness and the other retinal vessel morphology parameters.CONCLUSION: RNFL thickness increased significantly with suboptimality of arteriole branching coefficient. These findings cannot be explained by our current understanding of OCT. OCT-based biomarker metrics require further study to better define retinal neurovascular imaging and anatomy.",

keywords = "Aged, Cohort Studies, Female, Humans, Image Processing, Computer-Assisted, Male, Nerve Fibers, Retina, Retinal Vessels, Tomography, Optical Coherence",

author = "Grinton, {Michael E} and Augustinus Laude and Tom MacGillivray and Ross Henderson and Starr, {John M} and Deary, {Ian J} and Peter Aspinall and Baljean Dhillon",

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language = "English",

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T1 - The association between retinal vessel morphology and retinal nerve fiber layer thickness in an elderly population

AU - Grinton, Michael E

AU - Laude, Augustinus

AU - MacGillivray, Tom

AU - Henderson, Ross

AU - Starr, John M

AU - Deary, Ian J

AU - Aspinall, Peter

AU - Dhillon, Baljean

PY - 2012/8/14

Y1 - 2012/8/14

N2 - BACKGROUND AND OBJECTIVE: To investigate the relationship between retinal vessel morphology (branching coefficient, bifurcation angle, and fractal analysis) and retinal nerve fiber layer (RNFL) thickness in an elderly population.PATIENTS AND METHODS: One hundred and one participants from the Lothian Birth Cohort 1936 (population of people all born in 1936) were studied. RNFL thickness measurements (using optical coherence tomography [OCT]) and digital retinal photographs were collected. The retinal images were analyzed using custom-designed software called the Vascular Assessment and Measurement Platform for Images of the Retina.RESULTS: Greater deviation from the optimal arteriolar branching coefficient was associated with greater RNFL thickness (r = 0.249, P = .028). There was no significant association between RNFL thickness and the other retinal vessel morphology parameters.CONCLUSION: RNFL thickness increased significantly with suboptimality of arteriole branching coefficient. These findings cannot be explained by our current understanding of OCT. OCT-based biomarker metrics require further study to better define retinal neurovascular imaging and anatomy.

AB - BACKGROUND AND OBJECTIVE: To investigate the relationship between retinal vessel morphology (branching coefficient, bifurcation angle, and fractal analysis) and retinal nerve fiber layer (RNFL) thickness in an elderly population.PATIENTS AND METHODS: One hundred and one participants from the Lothian Birth Cohort 1936 (population of people all born in 1936) were studied. RNFL thickness measurements (using optical coherence tomography [OCT]) and digital retinal photographs were collected. The retinal images were analyzed using custom-designed software called the Vascular Assessment and Measurement Platform for Images of the Retina.RESULTS: Greater deviation from the optimal arteriolar branching coefficient was associated with greater RNFL thickness (r = 0.249, P = .028). There was no significant association between RNFL thickness and the other retinal vessel morphology parameters.CONCLUSION: RNFL thickness increased significantly with suboptimality of arteriole branching coefficient. These findings cannot be explained by our current understanding of OCT. OCT-based biomarker metrics require further study to better define retinal neurovascular imaging and anatomy.

KW - Aged

KW - Cohort Studies

KW - Female

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Male

KW - Nerve Fibers

KW - Retina

KW - Retinal Vessels

KW - Tomography, Optical Coherence

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DO - 10.3928/15428877-20120802-03

M3 - Article

C2 - 22882008

SN - 1938-2375

VL - 43

SP - S61-6

JO - Ophthalmic surgery, lasers & imaging

JF - Ophthalmic surgery, lasers & imaging

IS - 6 Suppl

ER -

The association between retinal vessel morphology and retinal nerve fiber layer thickness in an elderly population

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Keywords / Materials (for Non-textual outputs)

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