The association of a codon 136 PrP gene variant with the occurrence of natural scrapie

N Hunter, W Goldmann, G Smith, J Hope

Research output: Contribution to journalArticlepeer-review

Abstract

Incidence of both experimental and natural scrapie in sheep has been associated with polymorphisms of the PrP gene. In case/control studies the PrP allele which encodes valine at codon 136 (Val136) is found in 96-100% of naturally infected scrapie sheep of Shetland, Scottish Halfbred and Blue du Maine breeds. In contrast, in healthy animals from the same flocks, the most frequent allele encodes Ala136 (91-100% of sheep). However Val136 does not correlate with incidence of scrapie in two other flocks--Poll Dorsets and Suffolks--and there may therefore be breed differences in PrP genotypes affected by scrapie.
Original languageEnglish
Pages (from-to)171-7
Number of pages7
JournalArchives of Virology
Volume137
Issue number1-2
DOIs
Publication statusPublished - 1994

Keywords

  • Alleles
  • Animals
  • Codon
  • Genetic Variation
  • Genotype
  • Polymorphism, Genetic
  • Prions
  • Reference Values
  • Scotland
  • Scrapie
  • Sheep

Fingerprint Dive into the research topics of 'The association of a codon 136 PrP gene variant with the occurrence of natural scrapie'. Together they form a unique fingerprint.

Cite this