Abstract
Incidence of both experimental and natural scrapie in sheep has been associated with polymorphisms of the PrP gene. In case/control studies the PrP allele which encodes valine at codon 136 (Val136) is found in 96-100% of naturally infected scrapie sheep of Shetland, Scottish Halfbred and Blue du Maine breeds. In contrast, in healthy animals from the same flocks, the most frequent allele encodes Ala136 (91-100% of sheep). However Val136 does not correlate with incidence of scrapie in two other flocks--Poll Dorsets and Suffolks--and there may therefore be breed differences in PrP genotypes affected by scrapie.
Original language | English |
---|---|
Pages (from-to) | 171-7 |
Number of pages | 7 |
Journal | Archives of Virology |
Volume | 137 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - 1994 |
Keywords / Materials (for Non-textual outputs)
- Alleles
- Animals
- Codon
- Genetic Variation
- Genotype
- Polymorphism, Genetic
- Prions
- Reference Values
- Scotland
- Scrapie
- Sheep