The association of aphasia and right-sided motor impairment in corticobasal syndrome

Johannes Levin, Thomas H Bak, Axel Rominger, Erik Mille, Thomas Arzberger, Armin Giese, Nibal Ackl, Stefan Lorenzl, Benedikt Bader, Maximilian Patzig, Kai Bötzel, Adrian Danek

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Corticobasal syndrome is defined clinically on the basis of symptoms and findings related to dysfunction of the cerebral cortex and the basal ganglia. Usually, marked asymmetry of motor findings is observed. Although aphasia has now been recognized as a frequent feature of corticobasal syndrome, it remains unclear whether it is usually associated with right-sided motor symptoms, pointing to the involvement of the left hemisphere. Hence, we set out to examine the relationship between the presence of language symptoms and the side affected by extrapyramidal symptoms. We analyzed the electronic care records of patients seen in the years 2003-2013 in the Neurology Department of the University Hospital of Munich. The diagnosis of corticobasal syndrome was discussed in ninety-two individuals. Of those, 38 cases fulfilled diagnostic criteria for corticobasal syndrome. Aphasia correlated highly with a predominant right-sided movement disorder (p = 0.002). In contrast, it was less common in patients with left-sided motor presentation. Dysarthria did not show a preferential correlation (p = 0.25). Our analysis suggests a characteristic presentation of corticobasal syndrome in which motor dysfunction of the right side of the body is associated with aphasia.

Original languageEnglish
Number of pages6
JournalJournal of Neurology
Publication statusPublished - 5 Jul 2015


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