The association of genetic variation in CACNA1C with structure and function of a frontotemporal system

Fei Wang; Andrew M McIntosh; Yong He; Joel Gelernter; Hilary P Blumberg

doi:10.1111/j.1399-5618.2011.00963.x

The association of genetic variation in CACNA1C with structure and function of a frontotemporal system

Fei Wang, Andrew M McIntosh, Yong He, Joel Gelernter, Hilary P Blumberg

Research output: Contribution to journal › Article › peer-review

Abstract

A single nucleotide polymorphism at the CACNA1C gene (rs1006737) has been reported in genome-wide association studies to be associated with bipolar disorder (BD) with genome-wide significance. However, the neural system effects of CACNA1C that mediate the association are not known. In this study, we assessed associations between rs1006737 variation and both morphology and functional connectivity within a corticolimbic frontotemporal neural system implicated in BD.

Original language	English
Pages (from-to)	696-700
Number of pages	5
Journal	Bipolar Disorders
Volume	13
Issue number	7-8
DOIs	https://doi.org/10.1111/j.1399-5618.2011.00963.x
Publication status	Published - 2012

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10.1111/j.1399-5618.2011.00963.x

The association of genetic variation in CACNA1C with structure and function of a frontotemporal system
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http://onlinelibrary.wiley.com/doi/10.1111/j.1399-5618.2011.00963.x/abstract

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abstract = "A single nucleotide polymorphism at the CACNA1C gene (rs1006737) has been reported in genome-wide association studies to be associated with bipolar disorder (BD) with genome-wide significance. However, the neural system effects of CACNA1C that mediate the association are not known. In this study, we assessed associations between rs1006737 variation and both morphology and functional connectivity within a corticolimbic frontotemporal neural system implicated in BD.",

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AB - A single nucleotide polymorphism at the CACNA1C gene (rs1006737) has been reported in genome-wide association studies to be associated with bipolar disorder (BD) with genome-wide significance. However, the neural system effects of CACNA1C that mediate the association are not known. In this study, we assessed associations between rs1006737 variation and both morphology and functional connectivity within a corticolimbic frontotemporal neural system implicated in BD.

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The association of genetic variation in CACNA1C with structure and function of a frontotemporal system

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