The association of viral infection and chronic allograft nephropathy with graft dysfunction after renal transplantation

C Y William Tong, Ali Bakran, J S Malik Peiris, Peter Muir, C Simon Herrington

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

BACKGROUND: The long-term effect of viral infections on graft dysfunction and rejection after renal transplantation is uncertain.

METHODS: A cohort of 37 renal transplant recipients was followed prospectively for 3 years. Creatinine clearance rate at 6 months and 3 years and chronic allograft nephropathy were correlated with the detection of cytomegalovirus (CMV), human herpesvirus 6 and human herpesvirus 7 and BK virus DNA, CMV disease, and acute rejection.

RESULTS: CMV disease was significantly associated with poor graft function at 6 months, whereas chronic allograft nephropathy was associated with graft dysfunction at 3 years. Both CMV disease and detection of human herpesvirus 6 DNA were associated with chronic allograft nephropathy.

CONCLUSIONS: CMV disease was a significant cause of early graft dysfunction, whereas the presence of chronic allograft nephropathy was the main determinant of poor long-term graft function. The role of viral infections in chronic allograft nephropathy deserves further investigation.

Original languageEnglish
Pages (from-to)576-8
Number of pages3
JournalTransplantation
Volume74
Issue number4
DOIs
Publication statusPublished - 27 Aug 2002

Keywords / Materials (for Non-textual outputs)

  • BK Virus
  • Chronic Disease
  • Cohort Studies
  • Cytomegalovirus Infections
  • DNA, Viral
  • Herpesvirus 6, Human
  • Humans
  • Kidney
  • Kidney Diseases
  • Kidney Transplantation
  • Prospective Studies
  • Transplantation, Homologous

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