Projects per year
Abstract / Description of output
The spindle checkpoint coordinates the cell biology of mitosis with cell-cycle progression. It ensures that sister-chromatid separation only takes place when all kinetochores have formed stable bipolar microtubule attachments. Here, we discuss recent advances in our understanding of what activates this checkpoint pathway, the molecular nature of the checkpoint signal and its mode of transmission, and how the checkpoint might be inactivated.
| Original language | English |
|---|---|
| Pages (from-to) | 205-9 |
| Number of pages | 5 |
| Journal | Trends In Cell Biology |
| Volume | 12 |
| Issue number | 5 |
| Publication status | Published - 2002 |
Fingerprint
Dive into the research topics of 'The awesome power of multiple model systems: interpreting the complex nature of spindle checkpoint signaling'. Together they form a unique fingerprint.Projects
- 2 Finished
-
Isolation and characterisation of spindle checkpoint components from fission yeast and xenopus
1/10/98 → 30/09/01
Project: Research
-
Prize S/Ship to Mr D N Millband - The cellular & molecular basis of disease
Hardwick, K., Bard, J. & Maizels, R.
1/10/97 → 30/09/01
Project: Research