The baseline characteristics and interim analyses of the high-risk sentinel cohort of the Vietnam Initiative on Zoonotic InfectiONS (VIZIONS)

Juan J. Carrique-Mas*, Ngo T. Tue, Juliet E. Bryant, Karen Saylors, Nguyen V. Cuong, Ngo T. Hoa, Nguyen N. An, Vo B. Hien, Pham V. Lao, Nguyen C. Tu, Nguyen K. Chuyen, Nguyen T. K. Chuc, Dinh V. Tan, Hoang Van V. Duong, Tran K. Toan, Nguyen T. Y. Chi, James Campbell, Maia A. Rabaa, Behzad Nadjm, Mark WoolhouseHeiman Wertheim, Guy Thwaites, Stephen Baker

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The Vietnam Initiative for Zoonotic Infections (VIZIONS) includes community-based 'high-risk sentinel cohort' (HRSC) studies investigating individuals at risk of zoonotic infection due to occupational or residential exposure to animals. A total of 852 HRSC members were recruited between March 2013 and August 2014 from three provinces (Ha Noi, Dak Lak, and Dong Thap). The most numerous group (72.8%) corresponded to individuals living on farms, followed by slaughterers (16.3%) and animal health workers (8.5%). Nasal/pharyngeal and rectal swabs were collected from HRSC members at recruitment and after notifying illness. Exposure to exotic animals (including wild pigs, porcupine, monkey, civet, bamboo rat and bat) was highest for the Dak Lak cohort (53.7%), followed by Ha Noi (13.7%) and Dong Thap (4.0%). A total of 26.8% of individuals reported consumption of raw blood over the previous year; 33.6% slaughterers reported no use of protective equipment at work. Over 686 person-years of observation, 213 episodes of suspect infectious disease were notified, equivalent of 0.35 reports per person-year. Responsive samples were collected from animals in the farm cohort. There was noticeable time and space clustering of disease episodes suggesting that the VIZIONS set up is also suitable for the formal epidemiological investigation of disease outbreaks.

Original languageEnglish
Article number17965
Number of pages10
JournalScientific Reports
Volume5
DOIs
Publication statusPublished - 10 Dec 2015

Keywords

  • CONSUMPTION

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