The benefit of hypothermia in experimental ischemic stroke is not affected by pethidine

Emily S. Sena, Amy L. Jeffreys, Susan F. Cox, Stephen A. Sastra, Leonid Churilov, Sarah Rewell, Peter E. Batchelor, H. Bart van der Worp, Malcolm R. Macleod, David W. Howells*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Hypothermia is a promising experimental treatment for acute ischemic stroke. Human trials are still at an early stage, with the focus now on using hypothermia in awake patients. Pethidine (meperidine) is the principle agent used to control shivering in humans; however, whether it has any modulating effects on the neuroprotective efficacy of hypothermia is unknown.

The aim of this study was to determine if pethidine influences the neuroprotective effect of hypothermia in experimental stroke.

Seventy-two male spontaneously hypertensive rats were anesthetized with isoflurane and randomly assigned to either normothermia (37 center dot 4 degrees C rectal temperature); hypothermia (33 degrees C maintained for 130mins); normothermia plus pethidine (2 center dot 5mg/kg); or hypothermia plus pethidine. Temporary (90mins) endovascular occlusion of the middle cerebral artery was induced blinded to treatment allocation and was confirmed with laser Doppler flowmetry. Pethidine and cooling were started immediately after vessel occlusion. Animals in the normothermia group had active temperature management using a heat lamp and fan. Assessments of outcome were carried out 24 after the induction of injury.

Thirteen animals met our prespecified criteria for exclusion, and data for 59 rats were presented here. Hypothermia was associated with a 63% reduction in infarct size, and pethidine had no significant impact on the efficacy of hypothermia. No effects were observed in neurobehavioral outcome or edema volume across experimental groups.

The effects of hypothermia in a model of focal ischemia are not affected by administration of pethidine.

Original languageEnglish
Pages (from-to)180-185
Number of pages6
JournalInternational Journal of Stroke
Issue number3
Publication statusPublished - Apr 2013

Keywords / Materials (for Non-textual outputs)

  • ischemic stroke
  • intervention
  • hypertension
  • hypothermia
  • RATS
  • neuroprotection
  • acute stroke therapy


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