The biochemistry of mineralizing extracellular vesicles. Part I: The role of phosphatases

Flavia  Amadeu De Oliveira; Cintia  Tokuhara; Lucas Fabricio Bahia  Nogueira; Juçara Gastaldi  Cominal; Luiz Henrique  da Silva Andrilli; Sonoko Narisawa; Colin Farquharson; Massimo Bottini; Ana Paula  Ramos; Pietro Ciancaglini; José Luis Millán

doi:10.1016/B978-0-323-99158-2.00011-5

The biochemistry of mineralizing extracellular vesicles. Part I: The role of phosphatases

Flavia Amadeu De Oliveira, Cintia Tokuhara, Lucas Fabricio Bahia Nogueira, Juçara Gastaldi Cominal, Luiz Henrique da Silva Andrilli, Sonoko Narisawa, Colin Farquharson, Massimo Bottini, Ana Paula Ramos, Pietro Ciancaglini, José Luis Millán

Royal (Dick) School of Veterinary Studies

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

Abstract / Description of output

In this chapter, we will review some of the information regarding the functional significance of the inorganic phosphate (Pi)/pyrophosphate (PPi) ratio for physiological mineralization of hard tissues. We will recount the structure and function of the phosphatases involved in the regulation of this ratio: Tissue-nonspecific alkaline phosphatase (TNAP); Nucleotide Pyrophosphatases/Phosphodiesterase 1 (ENPP1); Na,K-ATPase; Nucleoside triphosphate diphosphohydrolase 1 (CD39); ecto-5′-nucleotidase (CD73) and orphan phosphatase 1 (PHOSPHO1); and how this knowledge has guided the development of protein therapeutics and of small molecule inhibitors to affect the Pi/PPi ratio in pathological conditions ranging from soft bones to ectopic calcification disorders.

Original language	English
Title of host publication	Mineralizing Vesicles: From Biochemical and Biophysical Properties to Their Roles in Physiology and Disease
Editors	Massimo Bottini, Ana Paula Ramos
Publisher	Academic Press
Chapter	5
Pages	95-126
Number of pages	32
ISBN (Print)	978-0-323-99158-2
DOIs	https://doi.org/10.1016/B978-0-323-99158-2.00011-5
Publication status	E-pub ahead of print - 12 Jan 2024

Keywords / Materials (for Non-textual outputs)

Tissue-nonspecific alkaline phosphatase
Nucleotide Pyrophosphatases/ Phosphodiesterases
Na,K-ATPase
Nucleoside triphosphate 1 diphosphohydrolase
ecto-5′-nucleotidase
PHOSPHO1

Access to Document

10.1016/B978-0-323-99158-2.00011-5

MVs BOOK - Chapter 7-Submitted-042823_Accepted author manuscript, 491 KBLicence: Creative Commons: Attribution (CC-BY)

Cite this

Amadeu De Oliveira, F., Tokuhara, C., Nogueira, L. F. B., Cominal, J. G., da Silva Andrilli, L. H., Narisawa, S., Farquharson, C., Bottini, M., Ramos, A. P., Ciancaglini, P., & Millán, J. L. (2024). The biochemistry of mineralizing extracellular vesicles. Part I: The role of phosphatases. In M. Bottini, & A. P. Ramos (Eds.), Mineralizing Vesicles: From Biochemical and Biophysical Properties to Their Roles in Physiology and Disease (pp. 95-126). Academic Press. Advance online publication. https://doi.org/10.1016/B978-0-323-99158-2.00011-5

@inbook{2362721221bc4d249d9fead4f9047eb8,

title = "The biochemistry of mineralizing extracellular vesicles. Part I: The role of phosphatases",

abstract = "In this chapter, we will review some of the information regarding the functional significance of the inorganic phosphate (Pi)/pyrophosphate (PPi) ratio for physiological mineralization of hard tissues. We will recount the structure and function of the phosphatases involved in the regulation of this ratio: Tissue-nonspecific alkaline phosphatase (TNAP); Nucleotide Pyrophosphatases/Phosphodiesterase 1 (ENPP1); Na,K-ATPase; Nucleoside triphosphate diphosphohydrolase 1 (CD39); ecto-5′-nucleotidase (CD73) and orphan phosphatase 1 (PHOSPHO1); and how this knowledge has guided the development of protein therapeutics and of small molecule inhibitors to affect the Pi/PPi ratio in pathological conditions ranging from soft bones to ectopic calcification disorders.",

keywords = "Tissue-nonspecific alkaline phosphatase, Nucleotide Pyrophosphatases/ Phosphodiesterases, Na,K-ATPase, Nucleoside triphosphate 1 diphosphohydrolase, ecto-5′-nucleotidase, PHOSPHO1",

author = "{Amadeu De Oliveira}, Flavia and Cintia Tokuhara and Nogueira, {Lucas Fabricio Bahia} and Cominal, {Ju{\c c}ara Gastaldi} and {da Silva Andrilli}, {Luiz Henrique} and Sonoko Narisawa and Colin Farquharson and Massimo Bottini and Ramos, {Ana Paula} and Pietro Ciancaglini and Mill{\'a}n, {Jos{\'e} Luis}",

year = "2024",

month = jan,

day = "12",

doi = "10.1016/B978-0-323-99158-2.00011-5",

language = "English",

isbn = "978-0-323-99158-2",

pages = "95--126",

editor = "Bottini, {Massimo } and Ramos, {Ana Paula }",

booktitle = "Mineralizing Vesicles: From Biochemical and Biophysical Properties to Their Roles in Physiology and Disease",

publisher = "Academic Press",

}

Amadeu De Oliveira, F, Tokuhara, C, Nogueira, LFB, Cominal, JG, da Silva Andrilli, LH, Narisawa, S, Farquharson, C, Bottini, M, Ramos, AP, Ciancaglini, P & Millán, JL 2024, The biochemistry of mineralizing extracellular vesicles. Part I: The role of phosphatases. in M Bottini & AP Ramos (eds), Mineralizing Vesicles: From Biochemical and Biophysical Properties to Their Roles in Physiology and Disease. Academic Press, pp. 95-126. https://doi.org/10.1016/B978-0-323-99158-2.00011-5

The biochemistry of mineralizing extracellular vesicles. Part I: The role of phosphatases. / Amadeu De Oliveira, Flavia; Tokuhara, Cintia ; Nogueira, Lucas Fabricio Bahia et al.
Mineralizing Vesicles: From Biochemical and Biophysical Properties to Their Roles in Physiology and Disease. ed. / Massimo Bottini; Ana Paula Ramos. Academic Press, 2024. p. 95-126.

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

TY - CHAP

T1 - The biochemistry of mineralizing extracellular vesicles. Part I: The role of phosphatases

AU - Amadeu De Oliveira, Flavia

AU - Tokuhara, Cintia

AU - Nogueira, Lucas Fabricio Bahia

AU - Cominal, Juçara Gastaldi

AU - da Silva Andrilli, Luiz Henrique

AU - Narisawa, Sonoko

AU - Farquharson, Colin

AU - Bottini, Massimo

AU - Ramos, Ana Paula

AU - Ciancaglini, Pietro

AU - Millán, José Luis

PY - 2024/1/12

Y1 - 2024/1/12

N2 - In this chapter, we will review some of the information regarding the functional significance of the inorganic phosphate (Pi)/pyrophosphate (PPi) ratio for physiological mineralization of hard tissues. We will recount the structure and function of the phosphatases involved in the regulation of this ratio: Tissue-nonspecific alkaline phosphatase (TNAP); Nucleotide Pyrophosphatases/Phosphodiesterase 1 (ENPP1); Na,K-ATPase; Nucleoside triphosphate diphosphohydrolase 1 (CD39); ecto-5′-nucleotidase (CD73) and orphan phosphatase 1 (PHOSPHO1); and how this knowledge has guided the development of protein therapeutics and of small molecule inhibitors to affect the Pi/PPi ratio in pathological conditions ranging from soft bones to ectopic calcification disorders.

AB - In this chapter, we will review some of the information regarding the functional significance of the inorganic phosphate (Pi)/pyrophosphate (PPi) ratio for physiological mineralization of hard tissues. We will recount the structure and function of the phosphatases involved in the regulation of this ratio: Tissue-nonspecific alkaline phosphatase (TNAP); Nucleotide Pyrophosphatases/Phosphodiesterase 1 (ENPP1); Na,K-ATPase; Nucleoside triphosphate diphosphohydrolase 1 (CD39); ecto-5′-nucleotidase (CD73) and orphan phosphatase 1 (PHOSPHO1); and how this knowledge has guided the development of protein therapeutics and of small molecule inhibitors to affect the Pi/PPi ratio in pathological conditions ranging from soft bones to ectopic calcification disorders.

KW - Tissue-nonspecific alkaline phosphatase

KW - Nucleotide Pyrophosphatases/ Phosphodiesterases

KW - Na,K-ATPase

KW - Nucleoside triphosphate 1 diphosphohydrolase

KW - ecto-5′-nucleotidase

KW - PHOSPHO1

U2 - 10.1016/B978-0-323-99158-2.00011-5

DO - 10.1016/B978-0-323-99158-2.00011-5

M3 - Chapter (peer-reviewed)

SN - 978-0-323-99158-2

SP - 95

EP - 126

BT - Mineralizing Vesicles: From Biochemical and Biophysical Properties to Their Roles in Physiology and Disease

A2 - Bottini, Massimo

A2 - Ramos, Ana Paula

PB - Academic Press

ER -

Amadeu De Oliveira F, Tokuhara C, Nogueira LFB, Cominal JG, da Silva Andrilli LH, Narisawa S et al. The biochemistry of mineralizing extracellular vesicles. Part I: The role of phosphatases. In Bottini M, Ramos AP, editors, Mineralizing Vesicles: From Biochemical and Biophysical Properties to Their Roles in Physiology and Disease. Academic Press. 2024. p. 95-126 Epub 2024 Jan 12. doi: 10.1016/B978-0-323-99158-2.00011-5

The biochemistry of mineralizing extracellular vesicles. Part I: The role of phosphatases

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

Access to Document

Fingerprint

Cite this