The biology of neurotrophins: Cardiovascular function

Costanza Emanueli, Marco Meloni, Wohaib Hasan, Beth A. Habecker*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter addresses the role of neurotrophins in the development of the heart, blood vessels, and neural circuits that control cardiovascular function, as well as the role of neurotrophins in the mature cardiovascular system. The cardiovascular system includes the heart and vasculature whose functions are tightly controlled by the nervous system. Neurons, cardiomyocytes, endothelial cells, vascular smooth muscle cells, and pericytes are all targets for neurotrophin action during development. Neurotrophin expression continues throughout life, and several common pathologies that impact cardiovascular function involve changes in the expression or activity of neurotrophins. These include atherosclerosis, hypertension, diabetes, acute myocardial infarction, and heart failure. In many of these conditions, altered expression of neurotrophins and/or neurotrophin receptors has direct effects on vascular endothelial and smooth muscle cells in addition to effects on nerves that modulate vascular resistance and cardiac function. This chapter summarizes the effects of neurotrophins in cardiovascular physiology and pathophysiology.

Original languageEnglish
Title of host publicationNeurotrophic Factors
EditorsGary Lewin, Bruce Carter
PublisherSpringer-Verlag
Pages309-328
Number of pages20
Volume220
ISBN (Electronic)978-3-642-45106-5
ISBN (Print)978-3-642-45105-8
DOIs
Publication statusPublished - 2014

Publication series

NameHandbook of Experimental Pharmacology

Keywords

  • Angiogenesis
  • BDNF
  • Cardiomyocytes
  • Diabetes
  • Hypertension
  • Myocardial ischemia
  • NGF
  • NT-3
  • P75NTR
  • Parasympathetic nervous system
  • Pericytes
  • Sympathetic nervous system
  • TrkA
  • TrkB
  • TrkC
  • Vascular endothelial growth factor-A (VEGF-A)

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