The BRICS (Bronchiectasis Radiologically Indexed CT Score)- a multi centre study score for use in idiopathic and post infective bronchiectasis

Pallavi Bedi; J D Chalmers; P C  Goeminne; C Mai; Pirakalathan Saravanamuthu; P Palanivenu; M K Cartlidge; M R  Loebinger; J Jacob; F Kamal; N Schembri; S Aliberti; U Hill; M Harrison; C Johnson; N Screaton; C Hawforth; E Polverino; E Rosales; A Torres; M N  Benegas; Adriano Rossi; D Patel; Adam Hill

doi:10.1016/j.chest.2017.11.033

The BRICS (Bronchiectasis Radiologically Indexed CT Score)- a multi centre study score for use in idiopathic and post infective bronchiectasis

Pallavi Bedi, J D Chalmers, P C Goeminne, C Mai, Pirakalathan Saravanamuthu, P Palanivenu, M K Cartlidge, M R Loebinger, J Jacob, F Kamal, N Schembri, S Aliberti, U Hill, M Harrison, C Johnson, N Screaton, C Hawforth, E Polverino, E Rosales, A TorresM N Benegas, Adriano Rossi, D Patel, Adam Hill

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Objectives
The aim of our study was to develop a simplified radiological score that could assess clinical disease severity in bronchiectasis.
Methods
The BRICS (Bronchiectasis Radiologically Indexed CT Score) was devised based
on multivariable analysis of the Bhalla score and their ability in predicting clinical
parameters of severity. The score was then externally validated in 6 centers in 302 patients.
Result
184 HRCT scans were scored for the validation cohort. In a multiple logistic
regression model, disease severity markers significantly associated with the Bhalla score were percentage predicted FEV1, sputum purulence and exacerbations requiring hospital admission. Components of the Bhalla score that were significantly associated with the disease severity markers were bronchial dilatation and number of bronchopulmonary segments with emphysema. The BRICS was developed with these two parameters. The receiver operator curve values for BRICS in the derivation cohort were 0.79 for percentage predicted FEV1, 0.71 for sputum purulence and 0.75 for hospital admissions/year; and 0.81, 0.70 and 0.70 respectively in the validation cohort. Sputum free neutrophil elastase was significantly elevated in the group with emphysema on CT.
Conclusion
A simplified CT scoring system can be used as an adjunct to clinical parameters to predict disease severity in patients with idiopathic and post-infective bronchiectasis.

Original language	English
Journal	Chest Journal
Early online date	13 Dec 2017
DOIs	https://doi.org/10.1016/j.chest.2017.11.033
Publication status	E-pub ahead of print - 13 Dec 2017

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Journal Article

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10.1016/j.chest.2017.11.033

BRICS accepted manuscript
Author's peer reviewed manuscript as accepted for publication.
Accepted author manuscript, 1.68 MBLicence: Creative Commons: Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND)

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Bedi, P., Chalmers, J. D., Goeminne, P. C., Mai, C., Saravanamuthu, P., Palanivenu, P., Cartlidge, M. K., Loebinger, M. R., Jacob, J., Kamal, F., Schembri, N., Aliberti, S., Hill, U., Harrison, M., Johnson, C., Screaton, N., Hawforth, C., Polverino, E., Rosales, E., ... Hill, A. (2017). The BRICS (Bronchiectasis Radiologically Indexed CT Score)- a multi centre study score for use in idiopathic and post infective bronchiectasis. Chest Journal. Advance online publication. https://doi.org/10.1016/j.chest.2017.11.033

@article{283d21ae5d2542dd8b05bb49b3acd140,

title = "The BRICS (Bronchiectasis Radiologically Indexed CT Score)- a multi centre study score for use in idiopathic and post infective bronchiectasis",

abstract = "ObjectivesThe aim of our study was to develop a simplified radiological score that could assess clinical disease severity in bronchiectasis.MethodsThe BRICS (Bronchiectasis Radiologically Indexed CT Score) was devised basedon multivariable analysis of the Bhalla score and their ability in predicting clinicalparameters of severity. The score was then externally validated in 6 centers in 302 patients.Result184 HRCT scans were scored for the validation cohort. In a multiple logisticregression model, disease severity markers significantly associated with the Bhalla score were percentage predicted FEV1, sputum purulence and exacerbations requiring hospital admission. Components of the Bhalla score that were significantly associated with the disease severity markers were bronchial dilatation and number of bronchopulmonary segments with emphysema. The BRICS was developed with these two parameters. The receiver operator curve values for BRICS in the derivation cohort were 0.79 for percentage predicted FEV1, 0.71 for sputum purulence and 0.75 for hospital admissions/year; and 0.81, 0.70 and 0.70 respectively in the validation cohort. Sputum free neutrophil elastase was significantly elevated in the group with emphysema on CT.ConclusionA simplified CT scoring system can be used as an adjunct to clinical parameters to predict disease severity in patients with idiopathic and post-infective bronchiectasis.",

keywords = "Journal Article",

author = "Pallavi Bedi and Chalmers, {J D} and Goeminne, {P C} and C Mai and Pirakalathan Saravanamuthu and P Palanivenu and Cartlidge, {M K} and Loebinger, {M R} and J Jacob and F Kamal and N Schembri and S Aliberti and U Hill and M Harrison and C Johnson and N Screaton and C Hawforth and E Polverino and E Rosales and A Torres and Benegas, {M N} and Adriano Rossi and D Patel and Adam Hill",

note = "Copyright {\textcopyright} 2017. Published by Elsevier Inc.",

year = "2017",

month = dec,

day = "13",

doi = "10.1016/j.chest.2017.11.033",

language = "English",

journal = "Chest Journal",

issn = "0012-3692",

publisher = "American College of Chest Physicians (ACCP) ",

}

Bedi, P, Chalmers, JD, Goeminne, PC, Mai, C, Saravanamuthu, P, Palanivenu, P, Cartlidge, MK, Loebinger, MR, Jacob, J, Kamal, F, Schembri, N, Aliberti, S, Hill, U, Harrison, M, Johnson, C, Screaton, N, Hawforth, C, Polverino, E, Rosales, E, Torres, A, Benegas, MN, Rossi, A, Patel, D & Hill, A 2017, 'The BRICS (Bronchiectasis Radiologically Indexed CT Score)- a multi centre study score for use in idiopathic and post infective bronchiectasis', Chest Journal. https://doi.org/10.1016/j.chest.2017.11.033

TY - JOUR

T1 - The BRICS (Bronchiectasis Radiologically Indexed CT Score)- a multi centre study score for use in idiopathic and post infective bronchiectasis

AU - Bedi, Pallavi

AU - Chalmers, J D

AU - Goeminne, P C

AU - Mai, C

AU - Saravanamuthu, Pirakalathan

AU - Palanivenu, P

AU - Cartlidge, M K

AU - Loebinger, M R

AU - Jacob, J

AU - Kamal, F

AU - Schembri, N

AU - Aliberti, S

AU - Hill, U

AU - Harrison, M

AU - Johnson, C

AU - Screaton, N

AU - Hawforth, C

AU - Polverino, E

AU - Rosales, E

AU - Torres, A

AU - Benegas, M N

AU - Rossi, Adriano

AU - Patel, D

AU - Hill, Adam

PY - 2017/12/13

Y1 - 2017/12/13

N2 - ObjectivesThe aim of our study was to develop a simplified radiological score that could assess clinical disease severity in bronchiectasis.MethodsThe BRICS (Bronchiectasis Radiologically Indexed CT Score) was devised basedon multivariable analysis of the Bhalla score and their ability in predicting clinicalparameters of severity. The score was then externally validated in 6 centers in 302 patients.Result184 HRCT scans were scored for the validation cohort. In a multiple logisticregression model, disease severity markers significantly associated with the Bhalla score were percentage predicted FEV1, sputum purulence and exacerbations requiring hospital admission. Components of the Bhalla score that were significantly associated with the disease severity markers were bronchial dilatation and number of bronchopulmonary segments with emphysema. The BRICS was developed with these two parameters. The receiver operator curve values for BRICS in the derivation cohort were 0.79 for percentage predicted FEV1, 0.71 for sputum purulence and 0.75 for hospital admissions/year; and 0.81, 0.70 and 0.70 respectively in the validation cohort. Sputum free neutrophil elastase was significantly elevated in the group with emphysema on CT.ConclusionA simplified CT scoring system can be used as an adjunct to clinical parameters to predict disease severity in patients with idiopathic and post-infective bronchiectasis.

AB - ObjectivesThe aim of our study was to develop a simplified radiological score that could assess clinical disease severity in bronchiectasis.MethodsThe BRICS (Bronchiectasis Radiologically Indexed CT Score) was devised basedon multivariable analysis of the Bhalla score and their ability in predicting clinicalparameters of severity. The score was then externally validated in 6 centers in 302 patients.Result184 HRCT scans were scored for the validation cohort. In a multiple logisticregression model, disease severity markers significantly associated with the Bhalla score were percentage predicted FEV1, sputum purulence and exacerbations requiring hospital admission. Components of the Bhalla score that were significantly associated with the disease severity markers were bronchial dilatation and number of bronchopulmonary segments with emphysema. The BRICS was developed with these two parameters. The receiver operator curve values for BRICS in the derivation cohort were 0.79 for percentage predicted FEV1, 0.71 for sputum purulence and 0.75 for hospital admissions/year; and 0.81, 0.70 and 0.70 respectively in the validation cohort. Sputum free neutrophil elastase was significantly elevated in the group with emphysema on CT.ConclusionA simplified CT scoring system can be used as an adjunct to clinical parameters to predict disease severity in patients with idiopathic and post-infective bronchiectasis.

KW - Journal Article

U2 - 10.1016/j.chest.2017.11.033

DO - 10.1016/j.chest.2017.11.033

M3 - Article

C2 - 29247616

SN - 0012-3692

JO - Chest Journal

JF - Chest Journal

ER -

The BRICS (Bronchiectasis Radiologically Indexed CT Score)- a multi centre study score for use in idiopathic and post infective bronchiectasis

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