Abstract / Description of output
Three capnellanes have been isolated fi om the soft coral Capnella imbricata. one known (1) and two new structures (9, 10). Their structures were determined by a mixture of spectroscopic methods and comparisons to the previous literature. Cytotoxicity against a panel of cancer cell lines was determined for all the compounds with compound 1 showing an IC50 of 0.7 mu M against K562 leukaemia. In addition compound 9 was cytotoxic to promyelogenous leukaemia and 10 was active against renal leiomyoblastoma cells. (C) 1998 Elsevier Science Ltd. All rights reserved.
Original language | English |
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Pages (from-to) | 12953-12958 |
Number of pages | 6 |
Journal | Tetrahedron |
Volume | 54 |
Issue number | 42 |
Publication status | Published - 15 Oct 1998 |
Keywords / Materials (for Non-textual outputs)
- MARINE-INVERTEBRATES
- SESQUITERPENE
- TERPENOIDS
- IMBRICATA