The capnellenes revisited: New structures and new biological activity

LA Morris, M Jaspars*, K Adamson, S Woods, HM Wallace

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Three capnellanes have been isolated fi om the soft coral Capnella imbricata. one known (1) and two new structures (9, 10). Their structures were determined by a mixture of spectroscopic methods and comparisons to the previous literature. Cytotoxicity against a panel of cancer cell lines was determined for all the compounds with compound 1 showing an IC50 of 0.7 mu M against K562 leukaemia. In addition compound 9 was cytotoxic to promyelogenous leukaemia and 10 was active against renal leiomyoblastoma cells. (C) 1998 Elsevier Science Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)12953-12958
Number of pages6
JournalTetrahedron
Volume54
Issue number42
Publication statusPublished - 15 Oct 1998

Keywords

  • MARINE-INVERTEBRATES
  • SESQUITERPENE
  • TERPENOIDS
  • IMBRICATA

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