The Carvedilol Hibernation Reversible Ischaemia Trial; Marker of Success (CHRISTMAS)

CHRISTMAS Study Steering Comm Inve, JGF Cleland*, D Pennel, S Ray, G Murray, P MacFarlane, A Cowley, A Coats, A Lahiri

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: Carvedilol improves left ventricular (LV) function when heart failure is due to LV systolic dysfunction, but the magnitude of the response is heterogeneous among patients with coronary disease, possibly reflecting the presence or volume of hibernating myocardium. Aims: The primary objective of the study is to determine whether the presence of hibernating myocardium predicts the magnitude of improvement in LV ejection fraction in response to carvedilol among patients with heart failure and LV systolic dysfunction due to coronary disease. Methods: The study is a prospective, randomised, parallel-group, double-blind, multi-centre study comparing carvedilol and placebo over a period of approximately 6 months in the above patient population. The primary end-point is the comparison of the mean change, from baseline to the final visit, in radionuclide-determined LV ejection fraction among patients on placebo with those on carvedilol stratified according to the presence of hibernating myocardium. Hibernating status will be determined by a combination of echocardiographic and myocardial perfusion (technetium-99m sestamibi) imaging. Results: 255 patients have undergone screening tests of which 207 have been randomised so far. The study intends to randomise 400 patients and the first report of results is expected in 2000. Conclusions: As far as we are aware this is the first randomised controlled trial to investigate the effects of treatment in patients stratified according to the presence of hibernating myocardium. The study will provide insights into the prevalence of myocardial hibernation, its natural history, and its influence on prognosis as well as the interaction between the presence of hibernating myocardium and the effects of treatment with carvedilol. (C) 1999 Published by European Society of Cardiology. All rights reserved.

Original languageEnglish
Pages (from-to)191-196
Number of pages6
JournalEuropean Journal of Heart Failure
Issue number2
Publication statusPublished - Jun 1999


  • heart failure
  • hibernating myocardium
  • beta-blockers

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