The cationic antimicrobial peptide LL-37 modulates dendritic cell differentiation and dendritic cell-induced T cell polarization

Donald J Davidson, Andrew J Currie, Gregor S D Reid, Dawn M E Bowdish, Kelly L MacDonald, Rebecca C Ma, Robert E W Hancock, David P Speert

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Dendritic cells (DC) are instrumental in orchestrating an appropriately polarized Th cell response to pathogens. DC exhibit considerable phenotypic and functional plasticity, influenced by lineage, Ag engagement, and the environment in which they develop and mature. In this study, we identify the human cationic peptide LL-37, found in abundance at sites of inflammation, as a potent modifier of DC differentiation, bridging innate and adaptive immune responses. LL-37-derived DC displayed significantly up-regulated endocytic capacity, modified phagocytic receptor expression and function, up-regulated costimulatory molecule expression, enhanced secretion of Th-1 inducing cytokines, and promoted Th1 responses in vitro. LL-37 may be an attractive therapeutic candidate for manipulating T cell polarization by DC.

Original languageEnglish
Pages (from-to)1146-56
Number of pages11
JournalThe Journal of Immunology
Volume172
Issue number2
Publication statusPublished - 15 Jan 2004

Keywords / Materials (for Non-textual outputs)

  • Adjuvants, Immunologic
  • Amino Acid Sequence
  • Animals
  • Antigens
  • Antimicrobial Cationic Peptides
  • Cathelicidins
  • Cattle
  • Cell Differentiation
  • Cell Division
  • Cells, Cultured
  • Chemotaxis
  • Cytokines
  • Dendritic Cells
  • Endocytosis
  • GTP-Binding Protein alpha Subunits, Gi-Go
  • Humans
  • Interferon-gamma
  • Molecular Sequence Data
  • Receptors, G-Protein-Coupled
  • Receptors, Immunologic
  • T-Lymphocyte Subsets
  • Th1 Cells

Fingerprint

Dive into the research topics of 'The cationic antimicrobial peptide LL-37 modulates dendritic cell differentiation and dendritic cell-induced T cell polarization'. Together they form a unique fingerprint.

Cite this