The Causes and Consequences of Changes in Virulence following Pathogen Host Shifts

Ben Longdon*, Jarrod D. Hadfield, Jonathan P. Day, Sophia C L Smith, John E. McGonigle, Rodrigo Cogni, Chuan Cao, Francis M. Jiggins

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Emerging infectious diseases are often the result of a host shift, where the pathogen originates from a different host species. Virulence—the harm a pathogen does to its host—can be extremely high following a host shift (for example Ebola, HIV, and SARs), while other host shifts may go undetected as they cause few symptoms in the new host. Here we examine how virulence varies across host species by carrying out a large cross infection experiment using 48 species of Drosophilidae and an RNA virus. Host shifts resulted in dramatic variation in virulence, with benign infections in some species and rapid death in others. The change in virulence was highly predictable from the host phylogeny, with hosts clustering together in distinct clades displaying high or low virulence. High levels of virulence are associated with high viral loads, and this may determine the transmission rate of the virus.

Original languageEnglish
Article numbere1004728
Number of pages18
JournalPLoS Pathogens
Issue number3
Publication statusPublished - 1 Jan 2015


Dive into the research topics of 'The Causes and Consequences of Changes in Virulence following Pathogen Host Shifts'. Together they form a unique fingerprint.

Cite this