The cellular Prion Protein: a player in immunological quiescence

Maren Bakkebo; Sophie Mouillet-Richard; Arild Espenes; Wilfred Goldmann; Jorg Tatzelt; Michael Tranulis

doi:10.3389/fimmu.2015.00450

The cellular Prion Protein: a player in immunological quiescence

Maren Bakkebo, Sophie Mouillet-Richard, Arild Espenes, Wilfred Goldmann, Jorg Tatzelt, Michael Tranulis

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Despite intensive studies since the 1990s, the physiological role of the cellular prion protein (PrPC) remains elusive. Here, we present a novel concept suggesting that PrPC contributes to immunological quiescence in addition to cell protection. PrPC is highly expressed in diverse organs that by multiple means are particularly protected from inflammation, such as the brain, eye, placenta, pregnant uterus and testes, while at the same time it is expressed in most cells of the lymphoreticular system. In this paradigm, PrPC serves two principal roles: to modulate the inflammatory potential of immune cells and to protect vulnerable parenchymal cells against noxious insults generated through inflammation. Here we review studies of PrPC physiology in view of this concept.

Original language	English
Article number	450
Pages (from-to)	1-12
Number of pages	12
Journal	Frontiers in Immunology
Volume	6
DOIs	https://doi.org/10.3389/fimmu.2015.00450
Publication status	Published - 2 Sept 2015

Keywords / Materials (for Non-textual outputs)

prion, immunological quiescence

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10.3389/fimmu.2015.00450

The cellular prion protein a player in immunological quiescence
Copyright: © 2015 Bakkebø, Mouillet-Richard, Espenes, Goldmann, Tatzelt and Tranulis. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Final published version, 800 KBLicence: Creative Commons: Attribution (CC-BY)

http://journal.frontiersin.org/article/10.3389/fimmu.2015.00450/abstract

Livestock neurobiology
Gill, A., Barron, R., Beard, P., Brunton, P., Goldmann, W., Hume, D., Hunter, N., Lawrence, A., Mabbott, N., Manson, J., McColl, B., Meddle, S. & Wishart, T.
BBSRC
1/04/12 → 31/03/17
Project: Research

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title = "The cellular Prion Protein: a player in immunological quiescence",

abstract = "Despite intensive studies since the 1990s, the physiological role of the cellular prion protein (PrPC) remains elusive. Here, we present a novel concept suggesting that PrPC contributes to immunological quiescence in addition to cell protection. PrPC is highly expressed in diverse organs that by multiple means are particularly protected from inflammation, such as the brain, eye, placenta, pregnant uterus and testes, while at the same time it is expressed in most cells of the lymphoreticular system. In this paradigm, PrPC serves two principal roles: to modulate the inflammatory potential of immune cells and to protect vulnerable parenchymal cells against noxious insults generated through inflammation. Here we review studies of PrPC physiology in view of this concept.",

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AU - Espenes, Arild

AU - Goldmann, Wilfred

AU - Tatzelt, Jorg

AU - Tranulis, Michael

PY - 2015/9/2

Y1 - 2015/9/2

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AB - Despite intensive studies since the 1990s, the physiological role of the cellular prion protein (PrPC) remains elusive. Here, we present a novel concept suggesting that PrPC contributes to immunological quiescence in addition to cell protection. PrPC is highly expressed in diverse organs that by multiple means are particularly protected from inflammation, such as the brain, eye, placenta, pregnant uterus and testes, while at the same time it is expressed in most cells of the lymphoreticular system. In this paradigm, PrPC serves two principal roles: to modulate the inflammatory potential of immune cells and to protect vulnerable parenchymal cells against noxious insults generated through inflammation. Here we review studies of PrPC physiology in view of this concept.

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The cellular Prion Protein: a player in immunological quiescence

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Keywords / Materials (for Non-textual outputs)

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Livestock neurobiology

Cite this