The chemical hunt for the identification of drugable targets

N C Meisner, M Hintersteiner, V Uhl, T Weidemann, M Schmied, H Gstach, M Auer

Research output: Contribution to journalLiterature reviewpeer-review


Chemical biology has emerged as a new scientific discipline to change the way scientists approach and study the interface between chemistry, biology and physics. By integrating the knowledge base of the human genome with the power of diverse and flexible chemical technology platforms, the ultimate goal is to define the 'rules of engagement' for small molecules and their use in basic biology and in drug discovery. Herein, we highlight the current counterpoles of the chemical biology philosophy in the framework between conformational diversity and informational complexity. Expanding the growing molecular recognition information matrix into classification of diseases and immediate mechanistic in-vivo proof of concept models represent the next development phase in a field that, unlike any other due to its multidisciplinary nature, unifies basic scientists and drug discoverers.

Original languageEnglish
Pages (from-to)424-431
Number of pages8
JournalCurrent opinion in chemical biology
Issue number4
Publication statusPublished - Aug 2004


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