The 'cognitive footprint' of psychiatric and neurological conditions: Cross-sectional study in the UK Biobank cohort

Objective: We aimed to quantify the prevalence of cognitive impairment in adults with a history of mood disorder, schizophrenia, multiple sclerosis or ParkiŶsoŶ͛s disease, within a large general population cohort.
Method: Cross-sectional study using UK Biobank data (n = 502,642). Psychiatric and neurological exposure status was ascertained via self-reported diagnoses, hospital records and questionnaires. Impairment on reasoning, reaction time and memory tests was defined with reference to a single unexposed comparison group. Results were standardised for age and gender. Sensitivity analyses examined the influence of comorbidity, education, information sources and missing data.
Results: Relative to the unexposed group, cognitive impairment was least common in major depression (standardised prevalence ratios across tests = 1.00 [95% CI 0.98, 1.02] to 1.49 [95% CI 1.24, 1.79]) and most common in schizophrenia (1.89 [95% CI 1.47, 2.42] to 3.92 [95% CI 2.34, 6.57]). Prevalence in mania/bipolar was similar to that in ŵultiple sĐlerosis aŶd ParkiŶsoŶ͛s disease. Estimated population attributable prevalence of cognitive impairment was higher for major depression (256 per 100,000 [95% CI 130, 381]) than for all other disorders.
Conclusion: Although the relative prevalence of cognitive impairment was lowest in major depression, the population attributable prevalence was highest overall for this group